Document Detail


Cardiovascular effects of acetaldehyde in guinea pigs.
MedLine Citation:
PMID:  7298149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hemodynamic effects of intravenous administration of acetaldehyde were determined in anesthetized control (group I), propranolol pretreated (group II) and phentolamine pretreated (group III) guinea pigs. Acetaldehyde produced an immediate and significant increase in mean arterial pressure followed by its progressive decrease resulting in hypotension. Heart rate increased significantly. In propranolol treated animals, acetaldehyde-induced tachycardia was not produced whereas in phentolamine treated animals, the initial pressor response was converted into a depressor one. Hence the increase in mean arterial pressure and heart rate produced by acetaldehyde are likely to be due to catecholamine release from adrenergic nerve endings.
Authors:
M Mohan; U C Rai; L P Reddy; C V Prasanna; S Ramakrishnan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  25     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    1981 Jul-Sep
Date Detail:
Created Date:  1982-01-28     Completed Date:  1982-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  246-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaldehyde / antagonists & inhibitors,  pharmacology*
Animals
Blood Pressure / drug effects
Electrocardiography
Female
Guinea Pigs
Heart Rate / drug effects
Hemodynamics / drug effects*
Male
Phentolamine / pharmacology
Propranolol / pharmacology
Chemical
Reg. No./Substance:
50-60-2/Phentolamine; 525-66-6/Propranolol; 75-07-0/Acetaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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