Document Detail


Cardiovascular effects of NT-1, a new patch form of nitroglycerin, alone and in combination with nifedipine in conscious dogs.
MedLine Citation:
PMID:  8932687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardiovascular effects of NT-1, a new patch form of nitroglycerin, alone and in combination with nifedipine in conscious dogs were examined. NT-1 (2.5 mg kg-1 nitroglycerin) decreased systolic blood pressure by 10-15%, while diastolic blood pressure and heart rate were not affected. Coronary blood flow and calculated rate-pressure product were decreased. These parameter changes occurred at 30 min after NT-1 application and remained constant for 8 h until NT-1 was removed. After administration of NT-1 in combination with nifedipine, systolic blood pressure was significantly decreased to a greater extent, and heart rate and coronary blood flow showed a tendency to increase compared with nifedipine alone. Rate-pressure product was not changed compared with that obtained on administration of nifedipine alone. These results suggest that NT-1 may be applicable as a transdermal sustained release medication, and show that in combination with nifedipine, NT-1 can induce a large increase in coronary blood flow without further increasing rate-pressure product.
Authors:
A Kanda; M Yoshida; M Kanou; K Yamaguchi; K Kyuki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  47     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1021-4     Citation Subset:  IM    
Affiliation:
Pharmacology Research Laboratories, Taiho Pharmaceutical Co., Ltd, Tokushima, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Coronary Circulation / drug effects
Delayed-Action Preparations
Dogs
Drug Interactions
Heart Rate / drug effects
Nifedipine / pharmacology*
Nitroglycerin / administration & dosage*
Vasodilator Agents / administration & dosage*
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Vasodilator Agents; 21829-25-4/Nifedipine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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