Document Detail

Cardiovascular effects of NT-1, a new patch form of nitroglycerin, alone and in combination with nifedipine in conscious dogs.
MedLine Citation:
PMID:  8932687     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of NT-1, a new patch form of nitroglycerin, alone and in combination with nifedipine in conscious dogs were examined. NT-1 (2.5 mg kg-1 nitroglycerin) decreased systolic blood pressure by 10-15%, while diastolic blood pressure and heart rate were not affected. Coronary blood flow and calculated rate-pressure product were decreased. These parameter changes occurred at 30 min after NT-1 application and remained constant for 8 h until NT-1 was removed. After administration of NT-1 in combination with nifedipine, systolic blood pressure was significantly decreased to a greater extent, and heart rate and coronary blood flow showed a tendency to increase compared with nifedipine alone. Rate-pressure product was not changed compared with that obtained on administration of nifedipine alone. These results suggest that NT-1 may be applicable as a transdermal sustained release medication, and show that in combination with nifedipine, NT-1 can induce a large increase in coronary blood flow without further increasing rate-pressure product.
A Kanda; M Yoshida; M Kanou; K Yamaguchi; K Kyuki
Related Documents :
17532677 - Effect of imidapril and nifedipine on left ventricular hypertrophy in untreated hyperte...
3725887 - Steady state verapamil tissue distribution in the dog: differing tissue accumulation.
3494367 - Slow-release nifedipine: effect on the circadian rhythm of blood pressure in essential ...
3323557 - Effects of angiotensin converting enzyme inhibitor and calcium channel blocker on normo...
3190587 - Infestation in the dog by the paralysis tick, ixodes holocyclus. 4. cardiovascular effe...
8246137 - Rwj 26629, a new potassium channel opener and vascular smooth muscle relaxant: a potent...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  47     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1021-4     Citation Subset:  IM    
Pharmacology Research Laboratories, Taiho Pharmaceutical Co., Ltd, Tokushima, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Cutaneous
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Coronary Circulation / drug effects
Delayed-Action Preparations
Drug Interactions
Heart Rate / drug effects
Nifedipine / pharmacology*
Nitroglycerin / administration & dosage*
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Vasodilator Agents; 21829-25-4/Nifedipine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  In-vitro platelet responses to arachidonic acid in the rat.
Next Document:  Mechanisms in inhibitory action of aclarubicin on contractility of rat aorta.