Document Detail

Cardiovascular and diuretic activity of kaurene derivatives of Xylopia aethiopica and Alepidea amatymbica.
MedLine Citation:
PMID:  11535360     Owner:  NLM     Status:  MEDLINE    
The extractives, crude and pure, of Alepidea amatymbica (AA) and Xylopia aethiopica (XA) were subjected to bioassay-directed phytochemical examination for potential cardiovascular and diuretic activity. All extractives and derivatives (XA/O, AA/1, xylopic acid, AA/3, AA/4, AA/5, AA/6, XA/1, XA/2, XA/3) displayed low toxicity, with LC(50) 0.5-5.0 ng/ml. For the first time, diterpene kaurenoids were reported to have significant systemic hypotensive and coronary vasodilatory effect accompanied with bradycardia. These effects were attributed to calcium antagonistic mechanism. The diuretic and natriuretic effects found were similar to the effects of chlorothiazide, suggesting inhibition of Na+ and K+ reabsorption in the early portion of the distal tubule. Further experiments are needed to elaborate the exact mechanisms of the hypotensive and diuretic effects of diterpene kaurenoids.
L I Somova; F O Shode; K Moodley; Y Govender
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  77     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-05     Completed Date:  2001-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  165-74     Citation Subset:  IM    
Department of Human Physiology, University of Durban-Westville, Private Bag X54001, Durban, South Africa.
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MeSH Terms
Antihypertensive Agents / pharmacology,  toxicity*
Coronary Circulation / drug effects
Diterpenes / pharmacology,  toxicity*
Diterpenes, Kaurane*
Diuresis / drug effects*
Diuretics / pharmacology,  toxicity*
Hemodynamics / drug effects
Lethal Dose 50
Muscle, Smooth, Vascular / drug effects
Plant Extracts / pharmacology,  toxicity*
Rats, Wistar
Structure-Activity Relationship
Vasodilation / drug effects
Reg. No./Substance:
0/Antihypertensive Agents; 0/Diterpenes; 0/Diterpenes, Kaurane; 0/Diuretics; 0/Plant Extracts; 34424-57-2/kaurene

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