Document Detail

Cardiovascular diseases and nitric oxide in humans.
MedLine Citation:
PMID:  11214429     Owner:  NLM     Status:  MEDLINE    
The production of nitric oxide is impaired in patients with clinical and instrumental signs of arteriosclerosis (chronic coronary heart disease, stable and unstable angina, myocardial infarction); the NO deficiency is assessed through the vascular response to the infusion of stimulating (acetycholine) or inhibiting (N-mono-methylarginine) substances upon NO synthesis. Also in hypertensive subjects a weak endothelium-dependent vascular relaxation was documented, but this phenomenon is not constant and is still to be confirmed. In hypercholesterolemic patients a hyporesponsive endothelium-dependent vasodilation has been well documented, lipid lowering agents (drugs, apheresis) improve endothelium function. In heart failure low NO levels are found proportionally to the severity of disease: the expression of No is depressed, but cytokine mediated i NOS expression is enhanced, causing exaggerated amounts of NO and producing myocyte damage or death. Interesting findings indicated NO inhalation as a useful tool for reducing pulmonary hypertension and congestive heart failure.
S Ferlito
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  48     ISSN:  0026-4725     ISO Abbreviation:  Minerva Cardioangiol     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-14     Completed Date:  2001-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  379-86     Citation Subset:  IM    
Chair of Internal Medicine, Garibaldi Hospital, University of Catania, Catania.
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MeSH Terms
Arteriosclerosis / etiology
Cardiovascular Diseases / etiology*
Heart Failure / etiology
Hypercholesterolemia / etiology
Hypertension / etiology
Nitric Oxide / physiology*
Reg. No./Substance:
10102-43-9/Nitric Oxide

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