Document Detail

Cardiovascular control during sleep in infants: Implications for Sudden Infant Death Syndrome.
MedLine Citation:
PMID:  20609624     Owner:  NLM     Status:  MEDLINE    
In infants the cardiorespiratory system undergoes significant functional maturation after birth and these changes are sleep-state dependent. Given the immaturity of these systems it is not surprising that infants are at risk of cardiorespiratory instability, especially during sleep. A failure of cardiovascular control mechanisms in particular is believed to play a role in the final event of Sudden Infant Death Syndrome (SIDS). The "triple risk model" describes SIDS as an event that results from the intersection of three overlapping factors: (1) a vulnerable infant, (2) a critical development period in homeostatic control, and (3) an exogenous stressor. This review summarises normal development of cardiovascular control during sleep in infants and describes the association of impaired cardiovascular control with the three overlapping factors proposed to be involved in SIDS pathogenesis.
Rosemary S C Horne; Nicole B Witcombe; Stephanie R Yiallourou; Sonia Scaillet; Gérard Thiriez; Patricia Franco
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-06
Journal Detail:
Title:  Sleep medicine     Volume:  11     ISSN:  1878-5506     ISO Abbreviation:  Sleep Med.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  615-21     Citation Subset:  IM    
Copyright Information:
Crown Copyright 2010. Published by Elsevier B.V. All rights reserved.
Ritchie Centre for Baby Health Research, Monash Institute of Medical Research, Monash University, Melbourne, Australia.
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MeSH Terms
Cardiovascular Physiological Processes*
Child Development / physiology*
Infant, Newborn
Posture / physiology*
Risk Factors
Sleep Stages / physiology*
Sudden Infant Death / epidemiology*

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