Document Detail


Cardiovascular consequences of weightlessness promote advances in clinical and trauma care.
MedLine Citation:
PMID:  16101467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular adaptations driven by exposure to weightlessness cause some astronauts to experience orthostatic intolerance upon return to Earth. Maladaptations of spaceflight that lead to hemodynamic instability are temporary, and therefore astronauts provide for researchers a powerful model to study cardiovascular dysfunction in terrestrial patients. Orthostatic intolerance in astronauts is linked to changes in the autonomic control of cardiovascular function, and so patients that suffer neurocardiogenic syncope may benefit from a greater understanding of the effects of spaceflight on the autonomic nervous system. In addition, appropriate autonomic compensation is fundamental to the maintenance of stable arterial pressures and brain blood flow in patients suffering traumatic bleeding injuries. The application of lower body negative pressure (LBNP), an experimental procedure used widely in aerospace physiology, induces autonomic and hemodynamic responses that are similar to actual hemorrhage and therefore may emerge as a useful experimental tool to simulate hemorrhage in humans. Observations that standing astronauts and severely injured patients are challenged to maintain venous return has contributed to the development of an inspiratory impedance threshold device that serves as a controlled "Mueller maneuver" and has the potential to reduce orthostatic intolerance in returning astronauts and slow the progression to hemorrhagic shock in bleeding patients. In this review, we focus on describing new concepts that have arisen from studies of astronauts, patients, and victims of trauma, and highlight the necessity of developing the capability of monitoring medical information continuously and remotely. Remote medical monitoring will be essential for long-duration space missions and has the potential to save lives on the battlefield and in the civilian sector.
Authors:
William H Cooke; Victor A Convertino
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current pharmaceutical biotechnology     Volume:  6     ISSN:  1389-2010     ISO Abbreviation:  Curr Pharm Biotechnol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-16     Completed Date:  2006-04-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100960530     Medline TA:  Curr Pharm Biotechnol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  285-97     Citation Subset:  IM    
Affiliation:
U.S. Army Institute of Surgical Research, 3400 Rawley E. Chambers Avenue, Bldg. 3611, Fort Sam Houston, TX 78234-6513, USA. william.cooke@amedd.army.mil
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Aerospace Medicine
Astronauts
Cardiovascular Physiological Phenomena*
Emergency Medicine*
Hemorrhage
Humans
Patients
Remote Consultation
Space Flight*
Syncope
Weightlessness / adverse effects*
Wounds and Injuries

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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