Document Detail

Cardiovascular consequences of primary antihypertensive therapy with prazosin hydrochloride.
MedLine Citation:
PMID:  6364759     Owner:  NLM     Status:  MEDLINE    
Ten patients with essential hypertension who had no end-organ damage were treated with prazosin, starting with a dose of 1 mg/day. The dose was titrated to a maximal tolerated dose not exceeding 20 mg/day in divided doses or until diastolic blood pressure decreased to 90 mm Hg or lower. Among this study population a statistically significant decrease in blood pressures was achieved in the supine, sitting and standing positions. Baseline studies were repeated after 8 weeks of continuous therapy. There was no significant change in peripheral plasma renin activity, serum aldosterone or urinary sodium excretion. Plasma volume increased significantly and the patient weight increased proportionately. Cardiac ejection fraction at rest did not change significantly after prazosin therapy. Exercise ejection fraction also was not changed significantly from baseline during therapy, and the exercise-induced increase in blood pressure was significantly blunted. No adverse effects of prazosin on cardiac function were detected in this short-term study.
S C Scharf; H B Lee; J P Wexler; M D Blaufox
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  53     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-03-07     Completed Date:  1984-03-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  32A-36A     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Heart / radionuclide imaging
Hemodynamics / drug effects*
Hypertension / drug therapy*
Middle Aged
Natriuresis / drug effects
Physical Exertion
Plasma Volume / drug effects
Prazosin / therapeutic use*
Pulse / drug effects
Quinazolines / therapeutic use*
Renin / blood
Stroke Volume / drug effects
Technetium / diagnostic use
Reg. No./Substance:
0/Quinazolines; 19216-56-9/Prazosin; 7440-26-8/Technetium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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