Document Detail

Cardiovascular consequences of correction of the anemia of renal failure with erythropoietin.
MedLine Citation:
PMID:  8301932     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to define the physiologic responses of the heart and peripheral circulation to chronic anemia using noninvasive measurements while eliminating confounding biochemical, pharmacologic and physiologic variables. Stable chronic hemodialysis patients were studied at the University Hospital based chronic dialysis unit and echocardiography laboratory before and after therapy with human recombinant erythropoietin (rHuEPO). Subjects included maintenance hemodialysis patients free of left ventricular regional wall motion abnormalities discernible by echocardiography, rhythm disturbance, significant valvular or ischemic heart disease. Two-dimensional echocardiograms and simultaneous targeted M-mode echocardiograms, phonocardiograms and externally acquired subclavian artery pulse tracings were used to measure whole blood viscosity, arterial blood gases and ionized calcium, complete blood count, electrolytes, creatinine, blood urea nitrogen (BUN), and inorganic phosphate. All measurements were made immediately post-dialysis before and after therapy with rHuEPO. The interval between pre- and post-rHuEPO studies was 8.3 +/- 2.3 months. We found that post-dialysis hematocrit rose from 24.7 +/- 0.9 to 36.4 +/- 0.9%, hemoglobin from 83 +/- 3 to 121 +/- 3 g/liter and whole blood viscosity from 2.87 +/- 0.11 to 3.71 +/- 0.18 centipoise (all, P < 0.001 after therapy with rHuEPO). The remaining biochemical measurements did not change. Heart rate fell from 83 +/- 3 to 77 +/- 3 beats/min (P = 0.013). Left ventricular preload and afterload were not statistically different before and after rHuEPO. Total vascular resistance rose from 1313 +/- 84 to 1568 +/- 129, P = 0.029. Cardiac output and cardiac index fell by 12 and 15% (P = 0.024 and 0.030), respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
S K Fellner; R M Lang; A Neumann; C Korcarz; K M Borow
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  44     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-03-04     Completed Date:  1994-03-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1309-15     Citation Subset:  IM    
Department of Medicine, University of Chicago, Illinois.
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MeSH Terms
Anemia / blood,  drug therapy*,  etiology*
Body Weight
Cardiovascular System / drug effects*,  physiopathology
Erythropoietin / therapeutic use*
Hemodynamics / drug effects
Kidney Failure, Chronic / complications*
Middle Aged
Models, Cardiovascular
Myocardial Contraction
Recombinant Proteins
Ventricular Function, Left
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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