Document Detail

Cardiovascular complications associated with chronic active Epstein-Barr virus infection.
MedLine Citation:
PMID:  19184184     Owner:  NLM     Status:  MEDLINE    
This study aimed to assess the outcome of cardiovascular diseases for patients with chronic active Epstein-Barr virus infection (CAEBV). The study enrolled 15 patients (7 boys and 8 girls) who fulfilled the diagnostic criteria for CAEBV, including 10 patients with T-cell type and 3 patients with natural killer (NK)-cell type. The median age at the CAEBV onset was 6.3 years (range, 1.2-17.8 years). Regular cardiologic studies were performed during the median follow-up period of 8 years (range, 2-20 years). Nine patients (60%) had cardiac diseases including coronary artery lesion (CAL) (n = 4, 44%), decreased left ventricular ejection fraction and pericardial effusion in (n = 3, 33%), complete atrioventricular block (n = 1), and sudden arrest (n = 1). The frequency of fever (78%, p = 0.04) or cytopenias (100%, p = 0.01), as the major symptom among patients with cardiac complications, was higher than among those without complications. The median time from disease onset to detection of CAL was 3.4 years (range, 1.8-8.6 years). The mean z-score increased to 3.98. Seven patients (78%) with cardiac complications died of disease progression, hematopoietic stem cell transplantation-related events, or both. In two patients, CAL regressed after allogeneic cord blood transplantation. Among CAEBV patients, CAL was the most common cardiac complication and could not be controlled without the eradication of EBV-infected T- and NK-cells.
Jun Muneuchi; Shouichi Ohga; Masataka Ishimura; Kazuyuki Ikeda; Kenichiro Yamaguchi; Akihiko Nomura; Hidetoshi Takada; Yasunobu Abe; Toshiro Hara
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-30
Journal Detail:
Title:  Pediatric cardiology     Volume:  30     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  274-81     Citation Subset:  IM    
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Antibodies, Viral / analysis
Cardiovascular Diseases / diagnosis,  epidemiology,  etiology*
Child, Preschool
Chronic Disease
DNA, Viral / analysis
Diagnosis, Differential
Diagnostic Techniques, Cardiovascular
Epstein-Barr Virus Infections / complications*,  epidemiology,  virology
Follow-Up Studies
Herpesvirus 4, Human / genetics,  immunology
Japan / epidemiology
Retrospective Studies
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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