| Cardiovascular comorbidities in patients with psoriatic arthritis: a systematic review. | |
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MedLine Citation:
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PMID: 22532629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Data regarding cardiovascular comorbidity and cardiovascular risk factors in patients with psoriatic arthritis (PsA) are limited. To evaluate the cardiovascular risk profile, a systematic literature search was performed to provide an extensive summary of all studies available on cardiovascular risk in PsA. METHODS: Medline, EMBASE and the Cochrane library were searched from January 1966 to April 2011 for English language articles on data concerning cardiovascular diseases and cardiovascular risk factors in PsA. Review articles, case reports and studies on psoriasis alone were excluded. RESULTS: Twenty-eight articles were included in this review. Studies on all-cause mortality revealed mixed results. Available data on cardiovascular disease appeared more consistent, indicating an increased cardiovascular mortality and morbidity in PsA. Commensurate with this, surrogate markers of subclinical atherosclerosis, arterial stiffness and cardiovascular risk factors, for example hypertension, dyslipidaemia, obesity and metabolic-related factors, were more prominent in PsA compared with controls. Suppression of inflammation was linked with a favourable effect on cardiovascular surrogate markers, for example carotid intima media thickness and endothelial dysfunction, in several (un)controlled studies. CONCLUSION: Most studies point towards an increased cardiovascular risk in PsA, broadly on a par with the risk level in rheumatoid arthritis, emphasising the need for similar cardiovascular risk management in both conditions. Further studies are needed to indicate whether inflammatory suppression or modification of traditional cardiovascular risk factors, or both, will reduce cardiovascular risk. |
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Authors:
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Anna Jamnitski; Deborah Symmons; Mike J L Peters; Naveed Sattar; Iain McInnes; Iain McIinnes; Michael T Nurmohamed |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-04-24 |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 72 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-07 Completed Date: 2013-03-12 Revised Date: 2013-03-20 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 211-6 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Jan van Breemen Research Institute/READE, Dr Jan van Breemenstraat 2, 1056 AB Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Psoriatic
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epidemiology* Cardiovascular Diseases / epidemiology* Comorbidity Humans Risk Factors |
| Comments/Corrections | |
Erratum In:
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Ann Rheum Dis. 2013 Mar;72(3):467 Note: McIinnes, Iain [corrected to McInnes, Iain] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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