Document Detail

Cardiovascular collapse associated with the use of methylmethacrylate.
MedLine Citation:
PMID:  8266779     Owner:  NLM     Status:  MEDLINE    
Methylmethacrylate has been used extensively in the United States since 1971 for the fixation of orthopedic prostheses. A chemical compound that generates a considerable amount of heat as it sets and hardens, it has been known to cause mild to moderate hypotension as well as cardiovascular collapse and death in some instances. Some of the purported etiologies of the untoward effects of methylmethacrylate include fat embolism, air embolism, bone marrow embolism, peripheral vasodilation, activation within the lungs of the clotting cascade, direct cardiovascular depressant effects of methylmethacrylate cement or monomer, and others. In this article, the use of methylmethacrylate in orthopedic procedures is reviewed, along with a discussion of some of the previously hypothesized causes of its side effects. Then a case report of its use in a 59-year-old woman with a pathological fracture of her left femur is presented. Finally, the implications for the anesthetist are noted, and suggested interventions to limit untoward effects with the use of methylmethacrylate are presented.
P W Pinto
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  AANA journal     Volume:  61     ISSN:  0094-6354     ISO Abbreviation:  AANA J     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-01-27     Completed Date:  1994-01-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0431420     Medline TA:  AANA J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  613-6     Citation Subset:  N    
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MeSH Terms
Femoral Fractures / surgery
Fractures, Spontaneous / surgery
Intraoperative Complications / chemically induced*,  nursing
Methylmethacrylates / adverse effects*
Middle Aged
Nurse Anesthetists
Shock / chemically induced*,  nursing
Reg. No./Substance:
0/Methylmethacrylates; 80-62-6/Methylmethacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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