Document Detail


Cardiovascular changes in labour associated with extradural analgesia using bupivacaine.
MedLine Citation:
PMID:  1218169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular changes were monitored continuously in 13 women during stimulated labour conducted under extradural analgesia with bupivacaine. Three solutions of bupivacaine (0.5% plain, 0.25% with adrenaline and 0.5% with adrenaline) were administered in a random fashion. The results show that the plain solution of bupivacaine was associated with a decrease in central venous pressure and an increase in maternal heart rate which approached statistical significance 40-45 min after administration. These changes did not occur when solutions containing adrenaline were used. The small number of patients and the random administration of the bupivacaine solutions make it difficult to establish the exact significance of the cardiovascular changes observed and a further within-patient study is required.
Authors:
J B Broadfield; I M Corall; J R Nicholson; L Strunin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  47     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-05-25     Completed Date:  1976-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1291-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anesthesia, Epidural*
Anesthesia, Obstetrical*
Bupivacaine / pharmacology*
Central Venous Pressure / drug effects
Epinephrine / administration & dosage,  pharmacology
Female
Fetal Heart / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Labor, Obstetric
Pregnancy
Uterine Contraction / drug effects
Chemical
Reg. No./Substance:
2180-92-9/Bupivacaine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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