Document Detail

Cardiovascular changes in labour associated with extradural analgesia using bupivacaine.
MedLine Citation:
PMID:  1218169     Owner:  NLM     Status:  MEDLINE    
Cardiovascular changes were monitored continuously in 13 women during stimulated labour conducted under extradural analgesia with bupivacaine. Three solutions of bupivacaine (0.5% plain, 0.25% with adrenaline and 0.5% with adrenaline) were administered in a random fashion. The results show that the plain solution of bupivacaine was associated with a decrease in central venous pressure and an increase in maternal heart rate which approached statistical significance 40-45 min after administration. These changes did not occur when solutions containing adrenaline were used. The small number of patients and the random administration of the bupivacaine solutions make it difficult to establish the exact significance of the cardiovascular changes observed and a further within-patient study is required.
J B Broadfield; I M Corall; J R Nicholson; L Strunin
Related Documents :
665989 - Clinical evaluation of etomidate as an induction agent.
15601269 - Randomised trial of intravenous infusion of ephedrine or mephentermine for management o...
24622919 - Effect of obstructive respiratory events on blood pressure and renal perfusion in a pig...
1501209 - Tiletamine hydrochloride in combination with zolazepam hydrochloride as an anaesthetic ...
25118309 - A taxonomy for mechanical ventilation: 10 fundamental maxims.
9796239 - Block distribution and cardiovascular effects of unilateral spinal anaesthesia by 0.5% ...
17044659 - Reference values in white europeans for the arterial pulse wave recorded by means of th...
22157849 - Effects of alterations of inspiratory oxygen fractions on heart rate variability.
16108409 - Pressure-support ventilation and diaphragm shortening in the rat model.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  47     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-05-25     Completed Date:  1976-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1291-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthesia, Epidural*
Anesthesia, Obstetrical*
Bupivacaine / pharmacology*
Central Venous Pressure / drug effects
Epinephrine / administration & dosage,  pharmacology
Fetal Heart / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Labor, Obstetric
Uterine Contraction / drug effects
Reg. No./Substance:
2180-92-9/Bupivacaine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Maternal and neonatal effects of 1% and 2% mepivacaine for lumbar extradural analgesia.
Next Document:  A double-blind trial of bupivacaine (Marcain) and etidocaine (Duranest) in extradural block for surg...