Document Detail


Cardiovascular changes following acute and chronic chemical lesions of the dorsal periaqueductal gray in conscious rats.
MedLine Citation:
PMID:  10412833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was carried out to investigate the effects of chemical lesions of dorsal periaqueductal gray (DPAG) on resting arterial pressure (AP) and heart rate (HR) as well as on cardiac baroreflex of conscious normotensive rats. Lesions were performed by bilateral microinjections of 150 mM NMDA into the DPAG (DPAG-lesion group). Controls were similarly injected with 165 mM NaCl (DPAG-sham group). Animals with chronic lesions confined only to the superior colliculus (SC-lesion group) were also used as controls of DPAG-lesion. Cardiovascular parameters were recorded 1 or 7 days after the microinjections of NMDA in acute and chronic groups, respectively. Cardiac baroreflex was assessed by measuring the HR responses to the intravenous injection of phenylephrine or sodium nitroprusside. Baroreflex was estimated by sigmoidal curve fitting of HR responses. An increased baroreflex gain was observed in chronic DPAG-lesion rats compared to both DPAG-sham (p < 0.01) and SC-lesion (p < 0.05) chronic groups. The chronic DPAG-lesion group showed also an elevation of both the tachycardia (p < 0.05) and bradycardia (p < 0.01) plateaus compared to chronic DPAG-sham rats, while the SC-lesion group showed an elevation of the bradycardia plateau only (p < 0.01). Similar results on baroreflex function were observed following acute lesion of the DPAG, i.e. an increase in baroreflex gain (p < 0.01) and the elevation of both tachycardia (p < 0.05) and bradycardia plateaus (p < 0.01) compared to the acute DPAG-sham group. Resting AP and HR did not differ among the chronic groups. In contrast, the acute lesion of the DPAG produced a reduction in AP (p < 0.01) accompanied by an increase in HR (p < 0.01). The present data suggest that the DPAG is involved in the tonic and reflex control of AP and HR in conscious rats. In addition, the SC seems to contribute to the baroreflex cardioinhibition.
Authors:
K N Sampaio; H Mauad; V C Biancardi; J L Barros; F T Amaral; L C Schenberg; E C Vasquez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  76     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-09-01     Completed Date:  1999-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  99-107     Citation Subset:  IM    
Affiliation:
Department of Physiological Sciences, Biomedical Center, Federal University of Espirito Santo, Vitoria, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology
Algorithms
Animals
Baroreflex / drug effects
Blood Pressure / drug effects,  physiology
Denervation
Excitatory Amino Acid Agonists / pharmacology
Heart Rate / drug effects,  physiology
Hemodynamics / drug effects,  physiology*
Male
Microinjections
N-Methylaspartate / pharmacology
Nitroprusside / pharmacology
Periaqueductal Gray / anatomy & histology,  physiology*
Phenylephrine / pharmacology
Rats
Rats, Wistar
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Excitatory Amino Acid Agonists; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine; 6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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