Document Detail

Cardiovascular cavities cast in silicone rubber as an adjunct to post-mortem examination of the heart.
MedLine Citation:
PMID:  2925290     Owner:  NLM     Status:  MEDLINE    
We used silicone rubber as a material for making post-mortem casts of cavities in 21 human hearts, 16 of them congenitally malformed, 13 after surgical reconstruction (Fontan and Norwood procedures) and 4 after reconstruction had been performed posts mortem for study purposes. The organs were either fresh, or had been perfusion fixed with formalin prior to casting. When suitable silicone rubber and catalyst were used, we found that casts allowed a very clear view of chamber morphology, and, where surgery had been performed, of any vascular constriction or distortion. We made casts of the aortic sinus and coronary arteries in 3 adult hearts, demonstrating the location and extent of indentation due to atheromatous deposits. The resilience and non-adhesiveness of the silicone rubber allowed casts to be extracted without recourse to corrosion. The surrounding tissues, with the exception of trapped trabeculations and valve structures, were then available for conventional pathological examination. We propose that the relatively simple technique has important applications, not practicable using earlier casting materials, for the study of cardiovascular morphology, and for post-mortem evaluation of stenosed or surgically reconstructed vessels.
P J Kilner; S Y Ho; R H Anderson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  22     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-04-27     Completed Date:  1989-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  99-107     Citation Subset:  IM    
Department of Paediatric Cardiology, Institute of Child Health, London, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aorta, Thoracic / pathology
Aortopulmonary Septal Defect / pathology
Arteries / pathology
Coronary Disease / pathology
Coronary Vessels / pathology
Fetal Heart / pathology
Heart Atria / pathology*
Heart Defects, Congenital / pathology*
Heart Septal Defects / pathology
Heart Ventricles / pathology*
Infant, Newborn
Models, Anatomic*
Pulmonary Artery / pathology
Silicone Elastomers*
Vena Cava, Superior / pathology
Reg. No./Substance:
0/Silicone Elastomers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Coexistent cardiac tumours and malformations of the heart.
Next Document:  Changes in body attitude as a function of posthypnotic suggestions.