Document Detail

Cardiovascular birth defects and antenatal exposure to female sex hormones.
MedLine Citation:
PMID:  7151638     Owner:  NLM     Status:  MEDLINE    
The etiological correlations of congenital heart diseases to antenatal exposure of pregnant women to sex hormones were studied retrospectively. Of a total of 15,535 women who delivered between the years 1975-1977, 91 had babies with congenital heart disease (frequency 5.80/00). From these babies 11 were born to 559 mothers who had taken during pregnancy hormones of the estrogen-progesterone type (frequency 190/00). The remaining 80 babies were born to 14,976 mothers who had not taken such hormones (frequency 50/00). The main reason for having been given hormones were: bleeding of the first trimester in 80%, and the pregnancy test in 20%. Both groups of mothers had the same possibility for being affected by factors causing congenital heart diseases. An attempt is made to correlate the structure of the hormones given, the cause and time of the administration, the outcome of the newborn, and the type of heart disease.
E Hadjigeorgiou; A Malamitsi-Puchner; D Lolis; P Lazarides; D Nicolopoulos; D Kaskarelis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  5     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1982  
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  61-7     Citation Subset:  IM    
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MeSH Terms
Estrogens / adverse effects
Gestational Age
Gonadal Steroid Hormones / adverse effects*
Heart Defects, Congenital / chemically induced*
Infant, Newborn
Progesterone / adverse effects
Reg. No./Substance:
0/Estrogens; 0/Gonadal Steroid Hormones; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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