Document Detail


Cardiovascular biomarkers in exhaled breath.
MedLine Citation:
PMID:  22824108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With each breath that we exhale, thousands of molecules are expelled in our breath, giving individuals a "breath-print" that can tell a lot about them and their state of health. Breath analysis is rapidly evolving as the new frontier in medical testing. The end of the 20th century and the beginning of the 21st century have arguably witnessed a revolution in our understanding of the constituents of exhaled breath and the development of the field of breath analysis and testing. Thanks to major breakthroughs in new technologies (infrared, electrochemical, chemiluminescence, and others) and the availability of mass spectrometers, the field of breath analysis has made considerable advances in the 21st century. Several methods are now in clinical use or nearly ready to enter that arena. Breath analysis has the potential to offer relatively inexpensive, rapid, noninvasive methods for detecting and/or monitoring a variety of diseases. Breath analysis also has applications in fields beyond medicine, including environmental monitoring, security, and others. This review will focus on exhaled breath as a potential source of biomarkers for medical applications with specific attention to applications (and potential applications) in cardiovascular disease.
Authors:
Frank S Cikach; Raed A Dweik
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  55     ISSN:  1873-1740     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-07-24     Completed Date:  2012-10-03     Revised Date:  2014-10-23    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-43     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis*
Breath Tests* / methods
Cardiovascular Diseases / diagnosis*,  metabolism,  physiopathology
Exhalation*
Humans
Nitric Oxide / analysis
Predictive Value of Tests
Prognosis
Volatile Organic Compounds / analysis
Grant Support
ID/Acronym/Agency:
HL081064/HL/NHLBI NIH HHS; HL095181/HL/NHLBI NIH HHS; HL107147/HL/NHLBI NIH HHS; P01 HL081064/HL/NHLBI NIH HHS; P01 HL107147/HL/NHLBI NIH HHS; R21 RR026231/RR/NCRR NIH HHS; RR026231/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Volatile Organic Compounds; 31C4KY9ESH/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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