Document Detail

Cardiovascular and biochemical responses to nebulised salbutamol in normal subjects.
MedLine Citation:
PMID:  6487508     Owner:  NLM     Status:  MEDLINE    
When conventional therapeutic doses of nebulised salbutamol were given to normal volunteers, there was a significant rise in pulse rate, systolic blood pressure and plasma glucose and a significant fall in diastolic blood pressure and serum potassium in comparison with placebo. Such changes may be potentially hazardous in certain situations. Patients with airways obstruction due to chronic bronchitis who have coexistent ischaemic heart disease or diuretic induced hypokalaemia may be at particular risk from the unwanted cardiovascular and biochemical responses to nebulised salbutamol.
S R Smith; C Ryder; M J Kendall; R Holder
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  18     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-12-20     Completed Date:  1984-12-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  641-4     Citation Subset:  IM    
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MeSH Terms
Albuterol / administration & dosage*,  pharmacology
Blood Glucose / analysis
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Potassium / blood
Pulse / drug effects
Reg. No./Substance:
0/Aerosols; 0/Blood Glucose; 18559-94-9/Albuterol; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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