Document Detail

Cardiovascular autonomic regulation in patients with 3243A > G mitochondrial DNA mutation.
MedLine Citation:
PMID:  15181978     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with the 3243A > G mutation in mitochondrial DNA (mtDNA) have an increased risk for cardiovascular morbidity and mortality. The function of the autonomic nervous system has not been evaluated in these patients. PATIENTS AND METHODS: Indices of 24-hour heart rate variability (HRV) and baroreflex sensitivity (BRS) were measured in 28 patients with 3243A > G. The results were compared to controls matched with respect to age, sex, the presence of hypertension and diabetes mellitus and the use of cardiac medication. Conventional time and spectral domain indices and fractal correlation properties of HRV were analysed. RESULTS: In spectral analysis of HRV, the ultra-low and very-low-frequency spectral components were lower in the patients than the controls (P < 0.05 for both). Furthermore, the short-term fractal scaling exponent was lower in the patients with 3243A > G compared to the controls (1.16 +/- 0.18 versus 1.28 +/- 0.13, P < 0.01). No significant associations were found between the HRV indices and the other characteristics of the patients with 3243A > G, such as the presence of diabetes or left ventricular hypertrophy, left ventricular systolic function, the severity of the disease or the degree of 3243A > G heteroplasmy. CONCLUSIONS: Patients with the 3243A > G mutation in mtDNA have abnormalities in the spectral and fractal characteristics of HRV suggesting altered cardiac autonomic regulation. The abnormalities are not clearly associated with clinical manifestations related to 3243A > G suggesting that mitochondrial dysfunction may affect the autonomic regulatory systems more directly.
Kirsi Majamaa-Voltti; Kari Majamaa; Keijo Peuhkurinen; Timo H M?kikallio; Heikki V Huikuri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of medicine     Volume:  36     ISSN:  0785-3890     ISO Abbreviation:  Ann. Med.     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-08     Completed Date:  2004-12-06     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  225-31     Citation Subset:  IM    
Department of Internal Medicine, University of Oulu, Finland.
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MeSH Terms
Autonomic Nervous System / physiopathology
Cardiovascular Diseases / genetics*,  physiopathology
Case-Control Studies
DNA, Mitochondrial / genetics*
Reg. No./Substance:
0/DNA, Mitochondrial

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