| Cardiovascular autonomic regulation in Non-Obese Diabetic (NOD) mice. | |
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MedLine Citation:
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PMID: 18166503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Non-Obese Diabetic (NOD) mice show profound pathomorphological changes in sympathetic ganglia during the development of type 1 diabetes mellitus. We tested the hypothesis that NOD mice represent an experimental model to investigate cardiovascular changes seen in humans with diabetic autonomic neuropathy. Blood glucose (BG) levels were measured once a week. Diabetes mellitus was diagnosed as BG levels exceeded 250 mg/dl twice. NOD mice that did not become diabetic served as control group. Blood pressure (BP) and heart rate (HR) were monitored by telemetry and baroreflex sensitivity (BRS) was calculated with the sequence method or with cross spectral analysis. The measurements were obtained before onset of diabetes and during the 4th week of diabetes. The onset of diabetes was accompanied by a continuous decline in HR (615+/-14 vs. 498+/-23 bpm), whereas BP values remained stable (108+/-2 vs. 111+/-2 mm Hg). The circadian HR rhythm increased in diabetic NOD mice. BRS was higher in diabetic NOD mice than in controls. Atropine reduced BRS more profoundly in diabetic mice compared to non-diabetic mice. Despite pathomorphological similarities of the diabetic autonomic neuropathy between patients with diabetes and diabetic NOD mice, the changes in blood pressure regulation are different. In conclusion the use of diabetic NOD mice as a functional model for human diabetes may be questioned. |
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Authors:
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Volkmar Gross; Jens Tank; Hans-Joachim Partke; Ralph Plehm; André Diedrich; Andrey C da Costa Goncalves; Friedrich C Luft; Jens Jordan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-31 |
Journal Detail:
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Title: Autonomic neuroscience : basic & clinical Volume: 138 ISSN: 1566-0702 ISO Abbreviation: Auton Neurosci Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-21 Completed Date: 2008-04-11 Revised Date: 2009-08-12 |
Medline Journal Info:
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Nlm Unique ID: 100909359 Medline TA: Auton Neurosci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 108-13 Citation Subset: IM |
Affiliation:
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Max Delbrück Center for Molecular Medicine, Berlin, Germany. vgross@mdc-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology Animals Arrhythmias, Cardiac / etiology, physiopathology* Autonomic Nervous System / physiopathology* Autonomic Nervous System Diseases / etiology, physiopathology* Baroreflex / drug effects, physiology Blood Glucose / physiology Blood Pressure / drug effects, physiology Bradycardia / etiology, physiopathology Chronobiology Disorders / etiology, physiopathology Diabetic Neuropathies / physiopathology* Disease Models, Animal Female Ganglia, Sympathetic / physiopathology Heart / drug effects, innervation*, physiopathology* Heart Rate / drug effects, physiology Mice Mice, Inbred NOD Muscarinic Antagonists / pharmacology Reproducibility of Results Telemetry |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Blood Glucose; 0/Muscarinic Antagonists |
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