| Cardiovascular autonomic neuropathy in spontaneously diabetic rats with and without application of EGb 761. | |
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MedLine Citation:
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PMID: 20886438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular autonomic neuropathy causes abnormalities in the diabetic heart with various clinical sequelae, including exercise intolerance, arrhythmias and painless myocardial infarction. Little is known about (ultra)structural alterations of the myocardial nervous network. On the assumption that this diabetes-specific neuropathy develops due to permanently increased oxidative stress by liberation of oxygen-free radicals, adjuvant application of antioxidative therapeutics appears promising in preventing or delaying long-term diabetic complications. We have investigated the effects of Ginkgo biloba extract (EGb 761), a radical scavenger, against diabetes-induced myocardial nervous damage in spontaneously diabetic BioBreeding/Ottawa Karlsburg (BB/OK) rats. Morphological and morphometric parameters were evaluated by electron microscopy. We used immunohistochemistry to investigate protein expression of protein gene product 9.5, S100 protein, and thyroxin hydroxylase as a neuronal marker. Alterations of cardiac sympathetic activity were measured using the in vivo 123I-metaiodobenzyl-guanidine imaging, and the immunofluorescent labeling of beta1-adrenergic receptors and adenylate cyclase. Our results revealed that A) Diabetes results in slight to moderate ultrastructural alterations (hydrops, disintegration of substructure) of autonomic nerve fibers and related Schwann cells in untreated BB diabetic rats; B) Cardiac sympathetic integrity and activity is impaired due to alterations in the presynaptic nerve terminals and the postsynaptic ß1-AR-AC coupling system; C) Pre-treatment of diabetic myocardium with EGb results in an improvement of most of these parameters compared to unprotected myocardium. In conclusion, EGb may act as a potent therapeutic adjuvant in diabetics with respect to cardiovascular autonomic neuropathy, which may contribute to the prevention of late complications in diabetes. |
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Authors:
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Rick Schneider; Klaus Welt; Wolfram Aust; Regina Kluge; Heinz Löster; Günther Fitzl |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histology and histopathology Volume: 25 ISSN: 1699-5848 ISO Abbreviation: Histol. Histopathol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
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Languages: eng Pagination: 1581-90 Citation Subset: IM |
Affiliation:
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Department of Surgery II, University of Leipzig, Leipzig, Germany. rick.schneider@medizin.uni-leipzig.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine
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diagnostic use Animals Autonomic Nervous System Diseases / etiology, pathology*, radionuclide imaging Diabetes Mellitus, Experimental / pathology*, radionuclide imaging Diabetic Cardiomyopathies / etiology, pathology, radionuclide imaging Diabetic Neuropathies / pathology*, radionuclide imaging Fluorescent Antibody Technique Free Radical Scavengers / pharmacology* Immunohistochemistry Male Microscopy, Electron, Transmission Myocardium / ultrastructure Plant Extracts / pharmacology* Radionuclide Imaging Radiopharmaceuticals / diagnostic use Rats |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/Ginkgo biloba extract 761; 0/Plant Extracts; 0/Radiopharmaceuticals; 77679-27-7/3-Iodobenzylguanidine |
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