Document Detail


Cardiovascular autonomic dysfunction in a novel rodent model of polycystic kidney disease.
MedLine Citation:
PMID:  19825515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autonomic dysfunction, hypertension and cardiovascular morbidity in end stage renal disease are critically linked, however there are limited models available to investigate this relationship and develop clinical interventions. This study aimed to define the relationship between hypertension and autonomic function in a new rodent model of polycystic kidney disease (PKD). Using measures of heart rate and systolic blood pressure variability (HRV, SBPV), and time domain analysis of cardiac and sympathetic baroreflex function, we compared the Lewis PKD model (LPK) to a Lewis control. Systolic BP and SBPV were significantly higher in LPK vs. Lewis (168+/-7 vs. 131+/-8mm Hg, P<or=0.01, total power: 11+/-3.1 vs. 1.3+/-0.3mm Hg/Hz(2), P<or=0.05). LPK has a higher resting HR (437+/-17 vs. 330+/-11 beats per minute [bpm], P<or=0.001) associated with reduced HRV (total power [1.7+/-0.3 vs. 4.6+/-1.1ms/Hz(2), P<or=0.01]). Atenolol decreased HR to a greater extent in the LPK (90+/-10 vs. 20+/-17bpm, P<or=0.001) while subsequent methylatropine administration produced a greater increase in Lewis HR (24+/-9 vs. 66+/-9bpm, P<or=0.01). No difference in intrinsic HR following both drugs existed. Cardiac baroreflex function was impaired in LPK vs. Lewis (0.6+/-0.4 vs. 1.2+/-0.2bpm/mm Hg P<or=0.05, and 0.3+/-0.1 vs. 3.1+/-0.6ms/mm Hg, P<or=0.001, respectively). The sympathetic baroreflex function curve was shifted upwards and towards the right in LPK (P<or=0.01). Sympathetic baroreflex gain was not altered. This data suggests that sympathetic hyperactivity and reduced vagal function underlies the hypertension and reduced cardiac baroreflex function in the LPK model.
Authors:
Joanne L Harrison; Cara M Hildreth; Stephen M Callahan; Ann K Goodchild; Jacqueline K Phillips
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-13
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  152     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  60-6     Citation Subset:  IM    
Affiliation:
Integrated Health Institute, Faculty of Health Sciences, Murdoch University, Perth WA, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology
Atenolol / pharmacology
Atropine Derivatives / pharmacology
Autonomic Nervous System / physiopathology*
Baroreflex / drug effects,  physiology
Blood Pressure / drug effects
Cardiovascular System / innervation*,  physiopathology*
Disease Models, Animal
Electrophysiologic Techniques, Cardiac / methods
Fourier Analysis
Heart Rate / drug effects
Hypertension / drug therapy,  physiopathology*
Male
Nitroprusside / pharmacology
Parasympatholytics / pharmacology
Polycystic Kidney, Autosomal Recessive / physiopathology*
Rats
Rats, Inbred Lew
Signal Processing, Computer-Assisted
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Atropine Derivatives; 0/Parasympatholytics; 15078-28-1/Nitroprusside; 29122-68-7/Atenolol; 31610-87-4/methylatropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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