| Cardiovascular assessment of asymptomatic patients with juvenile-onset localized and systemic scleroderma: 10 years prospective observation. | |
| | |
MedLine Citation:
|
PMID: 22103465 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objectives: The aim of the present study was non-invasive evaluation of the cardiovascular system in asymptomatic young adult patients with juvenile localized scleroderma (JLS) and juvenile systemic sclerosis (JSS). Methods: A group of 34 consecutive children with scleroderma were prospectively observed in the study. The control group (CG) consisted of 20 healthy subjects. In each subject 12-lead electrocardiographic, echocardiographic, ECG Holter, and ambulatory blood pressure monitoring examinations were performed at the baseline visit and after 10 years. Additionally, B-type natriuretic peptide (BNP) concentrations were measured after 10 years. Results: Examinations were performed in 13 patients with JLS and 15 with JSS at the final visit. Two children had died (one from each group). Four patients were alive but refused the final visit. After 10 years, a higher prevalence of ventricular extrasystoles (p = 0.01) and an elevated pulmonary arterial pressure (JLS: p = 0.04, JSS: p = 0.03) were observed in both groups, but in comparison with the controls there was no significant difference at the final visit. In JLS patients more cases of left ventricle diastolic dysfunction, hypertension, and sinus tachycardia were diagnosed at the final visit (p ≤ 0.05). More atrioventricular block episodes in both groups of scleroderma patients were observed. Over the 10 years, arterial hypertension was diagnosed in three patients from the JLS group and in two with JSS. There were no significant differences in BNP concentrations at the final visit. Conclusions: The results of the present study show that juvenile scleroderma seems to be more benign than adult-onset disease. This observational study shows subclinical, not severe, cardiac abnormalities in adult patients with juvenile-onset disease. |
| | |
Authors:
|
A Borowiec; R Dabrowski; J Wozniak; S Jasek; T Chwyczko; I Kowalik; E Musiej-Nowakowska; H Szwed |
Related Documents
:
|
3652485 - An assessment of posterior pituitary function in patients with sheehan's syndrome. 3991585 - Reversible tubular dysfunction in alcohol abuse. 1129905 - Uncomplicated hypospadias and anomalies of upper urinary tract. need for screening? 17987575 - Family history and age at the onset of upper urinary tract calculi. 20817695 - Prognostic value of endothelial microparticles in patients with heart failure. 22186115 - Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-21 |
Journal Detail:
|
Title: Scandinavian journal of rheumatology Volume: - ISSN: 1502-7732 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0321213 Medline TA: Scand J Rheumatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Ischaemic Heart Disease Department II, Institute of Cardiology , Warsaw , Poland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Decisions about life-sustaining measures in children: In whose best interests?
Next Document: Electron Transfer Across Modular Oligo-p-phenylene Bridges in Ru(bpy)<sub>2</sub>(bpy-ph<sub>n</sub...