Document Detail

Cardiovascular aspects of psoriasis: an updated review.
MedLine Citation:
PMID:  23347301     Owner:  NLM     Status:  MEDLINE    
Psoriasis, a systemic inflammatory disease, is associated with enhanced atherosclerosis and risk of cardiovascular (CV) disease, which may account for higher morbidity and mortality rates in psoriatic patients. It especially applies to younger psoriatic patients with more severe disease, reducing their life expectancy. The aim of the study was to review the literature on CV disease in psoriasis as well as the pathogenic mechanisms shared between psoriasis and atherosclerosis. Moreover, case-control and cohort studies published between 2006 and 2011 were selected for meta-analysis. The meta-analysis indicates elevated risk of cardiovascular events in psoriatic patients in relation to non-psoriatic controls (OR 1.28; 95% CI 1.18-1.38). It is suggested that the treatment of the inflammatory processes involved in the pathogenesis of both psoriasis and atherosclerosis may be beneficial in reducing the CV risk in psoriatic patients. Further in-depth investigations, including prospective studies, are needed to enable more effective management of psoriatic patients in the future.
Aldona Pietrzak; Joanna Bartosińska; Grazyna Chodorowska; Jacek C Szepietowski; Piotr Paluszkiewicz; Robert A Schwartz
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International journal of dermatology     Volume:  52     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-07-09     Revised Date:  2014-06-23    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  153-62     Citation Subset:  IM    
Copyright Information:
© 2013 The International Society of Dermatology.
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MeSH Terms
Atherosclerosis / immunology*,  mortality*,  therapy
Psoriasis / immunology*,  mortality*,  therapy
Risk Factors
Comment In:
Int J Dermatol. 2014 Jun;53(6):e337   [PMID:  24673198 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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