Document Detail


Cardiovascular alpha1-adrenoceptor subtypes: functions and signaling.
MedLine Citation:
PMID:  10772055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
alpha-Adrenoceptors (alpha1AR) are G protein-coupled receptors and include alpha1A, alpha1B, and alpha1D subtypes corresponding to cloned alpha1a, alpha1b, and alpha1d, respectively. alpha1AR mediate several cardiovascular actions of sympathomimetic amines such as vasoconstriction and cardiac inotropy, hypertrophy, metabolism, and remodeling. alpha1AR subtypes are products of separate genes and differ in structure, G protein-coupling, tissue distribution, signaling, regulation, and functions. Both alpha(1A)AR and alpha(1B)AR mediate positive inotropic responses. On the other hand, cardiac hypertrophy is primarily mediated by alpha(1A)AR. The only demonstrated major function of alpha(1D)AR is vasoconstriction. alpha1AR are coupled to phospholipase C, phospholipase D, and phospholipase A2; they increase intracellular Ca2+ and myofibrillar sensitivity to Ca2+ and cause translocation of specific phosphokinase C isoforms to the particulate fraction. Cardiac hypertrophic responses to alpha1AR agonists might involve activation of phosphokinase C and mitogen-activated protein kinase via Gq x alpha1AR subtypes might interact with each other and with other receptors and signaling mechanisms.
Authors:
D R Varma; X F Deng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  78     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  267-92     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada. dvarma@pharma.mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular Physiological Phenomena*
Cardiovascular System / drug effects*
Humans
Receptors, Adrenergic, alpha-1 / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, alpha-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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