| Cardiovascular adaptations to exercise training after uncomplicated acute myocardial infarction. | |
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MedLine Citation:
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PMID: 16141746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study examined the cardiovascular adaptations of an exercise training program and evaluated the role of peripheral vasodilator capacity in contributing to these adaptations after myocardial infarction. DESIGN: A total of 44 consecutive patients with uncomplicated myocardial infarction underwent 3 wks of exercise training. Controls (n = 12) with comparable myocardial infarction were selected from our database and were restricted to a program with minimal activity. All patients performed cardiopulmonary exercise testing with hemodynamic measurements. Forearm and calf reactive hyperemic flow were measured by venous occlusive plethysmography as indices of peripheral vasodilator capacity. RESULTS: Despite no change in arteriovenous oxygen difference at peak exercise after training, training resulted in significant increases in oxygen consumption, cardiac output, and stroke volume and a significant decrease in systemic vascular resistance at peak exercise (overall, P < 0.05). Calf reactive hyperemic flow increased significantly after training (P < 0.001), but forearm reactive hyperemic flow did not. Furthermore, increase in calf reactive hyperemic flow after training had a positive correlation with increases in peak cardiac output, stroke volume, and oxygen consumption after training and an inverse correlation with peak systemic vascular resistance. CONCLUSIONS: Exercise training improved exercise tolerance by improving hemodynamic responses to exercise after myocardial infarction. This improved exercise performance was linked to a training-induced increase in calf vasodilator capacity. |
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Authors:
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Masayuki Motohiro; Fumio Yuasa; Toshihiko Hattori; Tsutomu Sumimoto; Masaharu Takeuchi; Mutsuhito Kaida; Toshimitsu Jikuhara; Makoto Hikosaka; Tetsuro Sugiura; Toshiji Iwasaka |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: American journal of physical medicine & rehabilitation / Association of Academic Physiatrists Volume: 84 ISSN: 0894-9115 ISO Abbreviation: Am J Phys Med Rehabil Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-05 Completed Date: 2005-09-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803677 Medline TA: Am J Phys Med Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 684-91 Citation Subset: AIM; IM |
Affiliation:
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Second Department of Internal Medicine, Kansai Medical University, Moriguchi City, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Cardiac Output / physiology Exercise Test Exercise Therapy* Exercise Tolerance / physiology* Female Forearm / blood supply Hemodynamics / physiology Humans Leg / blood supply Male Middle Aged Myocardial Infarction / physiopathology, rehabilitation* Oxygen Consumption / physiology Plethysmography Regional Blood Flow Vascular Resistance / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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