Document Detail

Cardiovascular adaptations to exercise training after uncomplicated acute myocardial infarction.
MedLine Citation:
PMID:  16141746     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study examined the cardiovascular adaptations of an exercise training program and evaluated the role of peripheral vasodilator capacity in contributing to these adaptations after myocardial infarction. DESIGN: A total of 44 consecutive patients with uncomplicated myocardial infarction underwent 3 wks of exercise training. Controls (n = 12) with comparable myocardial infarction were selected from our database and were restricted to a program with minimal activity. All patients performed cardiopulmonary exercise testing with hemodynamic measurements. Forearm and calf reactive hyperemic flow were measured by venous occlusive plethysmography as indices of peripheral vasodilator capacity. RESULTS: Despite no change in arteriovenous oxygen difference at peak exercise after training, training resulted in significant increases in oxygen consumption, cardiac output, and stroke volume and a significant decrease in systemic vascular resistance at peak exercise (overall, P < 0.05). Calf reactive hyperemic flow increased significantly after training (P < 0.001), but forearm reactive hyperemic flow did not. Furthermore, increase in calf reactive hyperemic flow after training had a positive correlation with increases in peak cardiac output, stroke volume, and oxygen consumption after training and an inverse correlation with peak systemic vascular resistance. CONCLUSIONS: Exercise training improved exercise tolerance by improving hemodynamic responses to exercise after myocardial infarction. This improved exercise performance was linked to a training-induced increase in calf vasodilator capacity.
Masayuki Motohiro; Fumio Yuasa; Toshihiko Hattori; Tsutomu Sumimoto; Masaharu Takeuchi; Mutsuhito Kaida; Toshimitsu Jikuhara; Makoto Hikosaka; Tetsuro Sugiura; Toshiji Iwasaka
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  84     ISSN:  0894-9115     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  684-91     Citation Subset:  AIM; IM    
Second Department of Internal Medicine, Kansai Medical University, Moriguchi City, Osaka, Japan.
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MeSH Terms
Adaptation, Physiological / physiology*
Cardiac Output / physiology
Exercise Test
Exercise Therapy*
Exercise Tolerance / physiology*
Forearm / blood supply
Hemodynamics / physiology
Leg / blood supply
Middle Aged
Myocardial Infarction / physiopathology,  rehabilitation*
Oxygen Consumption / physiology
Regional Blood Flow
Vascular Resistance / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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