Document Detail

Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats.
MedLine Citation:
PMID:  20065492     Owner:  NLM     Status:  MEDLINE    
The effect of chronic treatment with fermented milk products containing bioactive tripeptides and plant sterols on blood pressure and vascular function was investigated in spontaneously hypertensive rats (SHR). Six-weeks old male SHR (n=36) were randomized into 4 groups by body weight and blood pressure to receive either Lactobacillus helveticus fermented standard milk product (containing tripeptides Ile-Pro-Pro, Val-Pro-Pro and Leu-Pro-Pro), test product with enzymatically produced tripeptides without or with plant sterols or control product without the active constituents for 8 weeks. Systolic blood pressure (SBP) was measured weekly using the tail-cuff method. Thoracic aorta and mesenteric artery were excised for vascular response measurements. At the end, SBP values vs. control product group were: standard product group -14 mmHg (P<0.05), test product group -12 mmHg and test product +sterols group -7 mmHg. The average daily tripeptide dose was 2.8-5.2 mg/kg. Total serum cholesterol in the test product +sterols group tended to be lower than in the test product group (P=0.10) whereas serum plant sterol (campesterol, sitosterol) concentrations were higher (P<0.001). In conclusion, bioactive tripeptide-containing milk products attenuated the blood pressure development in SHR. The plant sterols did not improve this effect. Vascular responses did not markedly differ between the groups, except that endothelium-derived hyperpolarizing factor (EDHF) -related aortic relaxation was demonstrated in the test product +sterols group.
P Jakala; E Pere; R Lehtinen; A Turpeinen; R Korpela; H Vapaatalo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  60     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-12     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  11-20     Citation Subset:  IM    
Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland.
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MeSH Terms
Acetylcholinesterase / blood
Antihypertensive Agents / analysis,  pharmacology*
Arteries / drug effects,  physiopathology
Blood Pressure / drug effects
Caseins / metabolism*
Cholesterol / blood
Cultured Milk Products* / chemistry
Hypertension / prevention & control*
Lactobacillus helveticus / metabolism
Oligopeptides / analysis,  pharmacology*
Phytosterols / analysis,  blood,  pharmacology*
Random Allocation
Rats, Inbred SHR
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 0/Caseins; 0/Oligopeptides; 0/Phytosterols; 0/isoleucyl-prolyl-proline; 0/leucyl-prolyl-proline; 0/valyl-prolyl-proline; 57-88-5/Cholesterol; EC

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