| Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 20065492 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of chronic treatment with fermented milk products containing bioactive tripeptides and plant sterols on blood pressure and vascular function was investigated in spontaneously hypertensive rats (SHR). Six-weeks old male SHR (n=36) were randomized into 4 groups by body weight and blood pressure to receive either Lactobacillus helveticus fermented standard milk product (containing tripeptides Ile-Pro-Pro, Val-Pro-Pro and Leu-Pro-Pro), test product with enzymatically produced tripeptides without or with plant sterols or control product without the active constituents for 8 weeks. Systolic blood pressure (SBP) was measured weekly using the tail-cuff method. Thoracic aorta and mesenteric artery were excised for vascular response measurements. At the end, SBP values vs. control product group were: standard product group -14 mmHg (P<0.05), test product group -12 mmHg and test product +sterols group -7 mmHg. The average daily tripeptide dose was 2.8-5.2 mg/kg. Total serum cholesterol in the test product +sterols group tended to be lower than in the test product group (P=0.10) whereas serum plant sterol (campesterol, sitosterol) concentrations were higher (P<0.001). In conclusion, bioactive tripeptide-containing milk products attenuated the blood pressure development in SHR. The plant sterols did not improve this effect. Vascular responses did not markedly differ between the groups, except that endothelium-derived hyperpolarizing factor (EDHF) -related aortic relaxation was demonstrated in the test product +sterols group. |
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Authors:
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P Jakala; E Pere; R Lehtinen; A Turpeinen; R Korpela; H Vapaatalo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 60 ISSN: 1899-1505 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-12 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 11-20 Citation Subset: IM |
Affiliation:
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Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland. pauliina.jakala@helsinki.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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blood Animals Antihypertensive Agents / analysis, pharmacology* Arteries / drug effects, physiopathology Blood Pressure / drug effects Caseins / metabolism* Cholesterol / blood Cultured Milk Products* / chemistry Hypertension / prevention & control* Lactobacillus helveticus / metabolism Male Oligopeptides / analysis, pharmacology* Phytosterols / analysis, blood, pharmacology* Random Allocation Rats Rats, Inbred SHR Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Caseins; 0/Oligopeptides; 0/Phytosterols; 0/isoleucyl-prolyl-proline; 0/leucyl-prolyl-proline; 0/valyl-prolyl-proline; 57-88-5/Cholesterol; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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