Document Detail

Cardiovascular actions of the calmodulin inhibitor felodipine.
MedLine Citation:
PMID:  6633675     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of intravenous (1.5-10 nmol X kg-1) and intracoronary (50 nmol) administration of felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2, 6-dimethyl-3-ethoxycarbonyl-5-methoxycarbonylpyridine, were studied in anaesthetized pigs. Following intravenous administration dose-dependent decreases were observed in left ventricular systolic blood pressure (up to 30%) and in the resistances of the systemic (up to 40%) and coronary vascular beds (up to 45%), whereas heart rate, cardiac output, myocardial contractility (regional and global), and left ventricular end-diastolic pressure were minimally affected. Myocardial blood flow increased independently of the dose (20%), while the coronary venous O2-content more than doubled. The concomitant decrease in myocardial O2-consumption (up to 30%) was dose-dependent in the range from 1.5-6.75 nmol X kg-1. Intracoronary administration of 50 nmol had only minor effects on global and regional myocardial performance but produced a doubling of the coronary blood flow which was accompanied by a 70% decrease in myocardial O2-extraction. O2-consumption decreased considerably more (35%) than after intravenous administration in spite of the minimal decrease in O2-demand (7%). We conclude that felodipine dilates both systemic and coronary blood vessels. Although the reduction in myocardial O2-consumption is primarily caused by the reduction in afterload, a direct effect on myocardial metabolism can also be involved.
P D Verdouw; B H Wolffenbuttel; M G Scheffer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  323     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  350-4     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / pharmacology*
Calmodulin / antagonists & inhibitors*
Coronary Circulation / drug effects
Heart / drug effects
Hemodynamics / drug effects*
Injections, Intravenous
Myocardium / metabolism
Nifedipine / analogs & derivatives*,  blood,  pharmacology
Oxygen Consumption / drug effects
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calmodulin; 21829-25-4/Nifedipine; 72509-76-3/Felodipine

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