| Cardiovascular actions of atrial natriuretic factor in sheep with cardiac failure. | |
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MedLine Citation:
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PMID: 7826554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study examines in detail the short-term cardiovascular actions of atrial natriuretic factor (ANF) in sheep with experimental low-output cardiac failure. Five conscious sheep, surgically implanted with a ventricular pacing wire, were paced at 220 beats/min for 14 days. Most clinical symptoms of congestive heart failure (CHF) were apparent after the 14 days, characterized by low cardiac output, high venous pressure, increased total peripheral resistance, increased plasma levels of ANF, noradrenaline, arginine vasopressin and renin, and marked fluid retention. On day 14 of pacing, intravenous infusion of ANF at 100 micrograms/h for 60 min restored cardiac output to prepacing values and reduced both total peripheral resistance and right atrial pressure. These effects were sustained throughout the infusion period. No change was seen in blood pressure, plasma renin, or noradrenaline levels. These hemodynamic changes, produced by short-term infusion of ANF, contrasted with those seen in normal sheep, where there was a fall in cardiac output with increased total peripheral resistance. These changes reflect a return toward normal of the left ventricular function curve. This is the first study to report that ANF improves cardiac function in conscious sheep with CHF, primarily by a vasodilator action to reduce cardiac preload, and suggests that ANF may be useful in treating the hemodynamic effects associated with cardiac failure. |
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Authors:
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D G Parkes; J P Coghlan; E A Cooper; M Routley; J G McDougall; B A Scoggins |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hypertension Volume: 7 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-02-23 Completed Date: 1995-02-23 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 905-12 Citation Subset: IM |
Affiliation:
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Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / blood, pharmacology* Cardiac Output / drug effects* Cardiac Output, Low / drug therapy, physiopathology Electrophysiology Heart Failure / drug therapy, physiopathology* Hemodynamics Norepinephrine / blood Renin / blood Sheep |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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