Document Detail

[Cardiovascular Risk of non-steroidal anti-inflammatory Drugs].
MedLine Citation:
PMID:  23032496     Owner:  NLM     Status:  In-Data-Review    
Classical non-steroidal anti-inflammatory drugs (NSAID) and new selective inhibitors of cyclooxygenase-2(Cox-2 inhibitors) have been successfully used for several decades in the treatment of patients with chronic pain. In addition of their well known adverse gastrointestinal effects, these drugs have been recognized during recent years to increase cardiovascular risk. This risk exists with all drugs belonging to these two therapeutic classes and can be explained by a blood pressure increasing effect and the development of endothelial dysfunction. It there therefore necessary to check blood pressure and the renal function before and during administration of a NSAID or a Cox-2 inhibitor, as well as hemoglobinemia in patients exhibiting an increased gastrointestinal risk. International recommendations propose to avoid the use of these drugs in patients at high cardiovascular risk. If not possible naproxen, co-administered or not with a proton pump inhibitor, should be used preferentially, since this drug is the safest with regard to cardiovascular risk.
M Hermann
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Praxis     Volume:  101     ISSN:  1661-8157     ISO Abbreviation:  Praxis (Bern 1994)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468093     Medline TA:  Praxis (Bern 1994)     Country:  Switzerland    
Other Details:
Languages:  ger     Pagination:  1309-14     Citation Subset:  IM    
Kardiovaskuläre Rehabilitation, Zürcher Höhenklinik Wald.
Vernacular Title:
Kardiovaskuläres Risiko von nicht-steroidalen Antirheumatika.
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