| Cardiovascular risk factors, nonalcoholic fatty liver disease, and carotid artery intima-media thickness in an adolescent population in southern Italy. | |
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MedLine Citation:
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PMID: 20457571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine, in an adolescent population, the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of NAFLD and cardiovascular risk factors with carotid artery intima-media thickness (IMT), a marker of subclinical atherosclerosis. The authors conducted a population-based study among 642 randomly selected adolescents aged 11-13 years in Reggio Calabria, southern Italy, between November 2007 and October 2008. Prevalences of overweight and obesity were 30.5% and 13.5%, respectively. The overall prevalence of NAFLD was 12.5%, increasing to 23.0% in overweight/obese adolescents. In univariate analysis, increased IMT was positively associated with the presence of NAFLD, body mass index (BMI), waist circumference, systolic blood pressure (all P's < 0.001), diastolic blood pressure (P = 0.006), gamma-glutamyl transpeptidase (P = 0.006), alanine aminotransferase (P = 0.007), and C-reactive protein (P = 0.008) and was inversely associated with high density lipoprotein cholesterol (P < 0.001). In multivariate analysis, NAFLD (P = 0.002), BMI (P = 0.004), waist circumference (P = 0.003), and systolic blood pressure (P = 0.005) retained significant associations. The authors conclude that NAFLD, BMI, waist circumference, and systolic blood pressure are independent markers of increased IMT in a random sample of adolescents. |
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Authors:
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Carmelo Antonio Caserta; Gaspare Maria Pendino; Angela Amante; Carmelo Vacalebre; Maria Teresa Fiorillo; Pasquale Surace; Arianna Messineo; Monica Surace; Saverio Alicante; Rodolfo Cotichini; Massimo Zuin; Francesco Rosmini; Alfonso Mele; Fabrizio Marcucci |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-09 |
Journal Detail:
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Title: American journal of epidemiology Volume: 171 ISSN: 1476-6256 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 1195-202 Citation Subset: IM |
Affiliation:
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Madonna della Consolazione Hospital, Reggio Calabria, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alanine Transaminase / blood Atherosclerosis / epidemiology*, pathology Biological Markers / blood Blood Pressure Body Mass Index C-Reactive Protein / analysis Cardiovascular Diseases / epidemiology, pathology Carotid Arteries / anatomy & histology*, pathology, ultrasonography Cholesterol, HDL / blood Fatty Liver / epidemiology*, pathology Female Humans Italy / epidemiology Liver / pathology, ultrasonography Male Multivariate Analysis Obesity / epidemiology Prevalence Risk Factors Sex Factors Tunica Intima / anatomy & histology, pathology Tunica Media / anatomy & histology, pathology Waist Circumference gamma-Glutamyltransferase / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholesterol, HDL; 9007-41-4/C-Reactive Protein; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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