Document Detail

Cardiovascular responses and differential changes in mitogen-activated protein kinases following repeated episodes of binge drinking.
MedLine Citation:
PMID:  22878590     Owner:  NLM     Status:  MEDLINE    
AIMS: Excessive alcohol use in the form of binge drinking is associated with many adverse medical outcomes. Using an animal model, the primary objective of this study was to determine the effects of repeated episodes of binge drinking on myocardial structure, blood pressure (BP) and activation of mitogen-activated protein kinases (MAPKs). The effects of carvedilol, a beta-adrenergic blocker, were also examined in this animal model of binge drinking.
METHODS: Rats were randomized into three groups: control, binge and binge + carvedilol (20 mg/kg). Animals received intragastric administration of 5 g ethanol/kg in the morning × 4 days (Monday-Thursday) followed by no ethanol on Friday-Sunday. Animals were maintained on the protocol for 5 weeks. BP was measured using radiotelemetry methods. Animals underwent echocardiography at baseline, 2.5 and 5 weeks. Myocardial MAPKs were analyzed at 5 weeks using western blot techniques.
RESULTS: Over the course of 5 weeks, binge drinking was associated with significant transient increases in BP that were greater at 4 and 5 weeks compared with earlier time points. Carvedilol treatment significantly attenuated the binge-induced transient increases in BP at 4 and 5 weeks. No significant changes were found in echocardiographic parameters at any time period; however, binge drinking was associated with increased phosphorylation of p38 MAPK, which was blocked by carvedilol treatment.
CONCLUSION: Repeated episodes of binge drinking result in progressive and transient increases in BP, no change in myocardial structure and differential regulation of MAPK activation.
Lianzhi Gu; Anne M Fink; Shamim A K Chowdhury; David L Geenen; Mariann R Piano
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-08
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  48     ISSN:  1464-3502     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-10-28     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-7     Citation Subset:  IM    
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MeSH Terms
Adrenergic Antagonists / pharmacology,  therapeutic use
Binge Drinking / drug therapy,  enzymology*,  physiopathology*
Blood Pressure / drug effects,  physiology
Carbazoles / pharmacology,  therapeutic use
Enzyme Activation / drug effects,  physiology
Gastric Mucosa / drug effects,  enzymology,  physiopathology
Mitogen-Activated Protein Kinases / antagonists & inhibitors,  metabolism*
Pilot Projects
Propanolamines / pharmacology,  therapeutic use
Random Allocation
Rats, Sprague-Dawley
Recurrence / prevention & control
Time Factors
Grant Support
Reg. No./Substance:
0/Adrenergic Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol; EC Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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