Document Detail


Cardiovascular Properties of a Nitric Oxide Releasing Rofecoxib Analogue: Beneficial Anti-hypertensive Activity and Enhanced Recovery in an Ischemic Reperfusion Injury Model.
MedLine Citation:
PMID:  22689528     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Good news for the heart: The chronic use of rofecoxib causes adverse cardiovascular complications that prompted its withdrawal from the market. We recently modified rofecoxib into an NO-releasing, potent anti-inflammatory drug. Herein we describe the beneficial anti-hypertensive effects of the NO-releasing SO(2) NHOH COX-2 pharmacophore on blood pressure and its ability to enhance recovery in a cardiac ischemic reperfusion injury model.
Authors:
Atul Bhardwaj; Sri N Batchu; Jatinder Kaur; Zhangjian Huang; John M Seubert; Edward E Knaus
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-11
Journal Detail:
Title:  ChemMedChem     Volume:  -     ISSN:  1860-7187     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101259013     Medline TA:  ChemMedChem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2N8 (Canada).
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