Document Detail


Cardiovascular Magnetic Resonance Determinants of Left Ventricular Noncompaction.
MedLine Citation:
PMID:  24934759     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Insufficient precision remains in accurately identifying left ventricular noncompaction (LVNC) from the healthy normal morphologic spectrum. We aim to provide a better distinction between normal left ventricular trabeculations and LVNC. We used a previously well-defined cohort of 120 healthy volunteers for normal reference values of the trabecular/compacted ratio derived from a consistent selection of short-axis cardiovascular magnetic resonance images. We performed forward selection of logistic regression models, selecting the best model that was subsequently assessed for discrimination and calibration, validated, and converted into a clinical diagnostic chart to benchmark the boundaries of detection from a cohort of 30 patients considered to have LVNC. We showed that 3 combinations of a maximal end-diastolic trabecular/compacted ratio (≥1 [apex], >1.8 [midcavity]), (>2 [apex], ≥0.6 [midcavity]), or (>0.5 [base], >1.8 [midcavity]) separate the cohorts with the highest accuracy (C statistic [95% confidence interval] of 0.9749 (0.9748 to 0.9751) for the diagnostic chart). Quantitative cardiovascular magnetic resonance also shows that patients considered to have LVNC have a significantly reduced ejection fraction compared with normal volunteers. At midcavity and apical level, it is difficult to identify papillary muscles that are replaced by a dense trabecular meshwork. In conclusion, we developed a new, refined, diagnostic tool for identifying LVNC, based on an a priori assessment of the trabecular architecture in healthy volunteers.
Authors:
Dana K Dawson; David J McLernon; Vimal J Raj; Alicia M Maceira; Sanjay Prasad; Michael P Frenneaux; Dudley J Pennell; Philip J Kilner
Related Documents :
18193279 - Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional ste...
22347979 - A comparison between histopathology and findings on magnetic resonance imaging of subcu...
15794849 - Ventralis intermedius plus ventralis oralis anterior and posterior deep brain stimulati...
21593689 - Feasibility of intraoperative mri guidance for craniotomy and tumor resection in the se...
21750139 - Development of a risk score to guide brain imaging in older patients admitted with fall...
21978669 - Cardiovascular magnetic resonance activity in the united kingdom: a survey on behalf of...
23086529 - Ln(3+)-doped nanoparticles for upconversion and magnetic resonance imaging: some critic...
25378209 - Use of pet/ct instead of ct-only when planning for radiation therapy does not notably i...
2121509 - Analysis of radiolucent gallstones by computed tomography for in vivo estimation of sto...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-17
Journal Detail:
Title:  The American journal of cardiology     Volume:  -     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-6-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Usefulness of QRS Voltage Correction by Body Mass Index to Improve Electrocardiographic Detection of...
Next Document:  Proteinuria in adults with sickle-cell disease: the role of hydroxycarbamide(hydroxyurea) as a prote...