| Cardiovascular and Hormonal Effects of Domperidone, A Peripheral Dopaminergic Blocker, in Bromocriptine-Treated Hypertensive Patients. | |
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MedLine Citation:
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PMID: 11850690 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Nine patients with mild or moderate essential hypertension were studied at the Vargas Hospital of Caracas, Venezuela. After antihypertensive treatment discontinuation, all patients were placed on placebo during a 1-week period, after which domperidone, a peripheral DA(2) dopaminergic blocker, was orally administered at the dose of 20 mg every 12 h during a period of 1 week. A final 1-week period of bromocriptine, 2.5 mg orally every 8 h, followed the domperidone period. Cold pressor test caused an increase of mean blood pressure and of heart rate, which was more accentuated after adding bromocriptine. Domperidone also caused an increase of serum aldosterone levels. Our results suggest that a dopaminergic mechanism is acting during the cold pressor test and during aldosterone secretion. |
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Authors:
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Manuel Velasco; Ramón Arreaza; Augusta Luchsinger; Juanita Gómez; Eduardo Morales |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: American journal of therapeutics Volume: 2 ISSN: 1536-3686 ISO Abbreviation: Am J Ther Publication Date: 1995 Jul |
Date Detail:
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Created Date: 2002-Feb-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: - |
Other Details:
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Languages: ENG Pagination: 451-454 Citation Subset: - |
Affiliation:
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Section of Clinical Pharmacology, Vargas Medical School, Central University of Venezuela, Caracas, Venezuela. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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