Document Detail

Cardiovascular function in the heat-stressed human.
MedLine Citation:
PMID:  20345414     Owner:  NLM     Status:  MEDLINE    
Heat stress, whether passive (i.e. exposure to elevated environmental temperatures) or via exercise, results in pronounced cardiovascular adjustments that are necessary for adequate temperature regulation as well as perfusion of the exercising muscle, heart and brain. The available data suggest that generally during passive heat stress baroreflex control of heart rate and sympathetic nerve activity are unchanged, while baroreflex control of systemic vascular resistance may be impaired perhaps due to attenuated vasoconstrictor responsiveness of the cutaneous circulation. Heat stress improves left ventricular systolic function, evidenced by increased cardiac contractility, thereby maintaining stroke volume despite large reductions in ventricular filling pressures. Heat stress-induced reductions in cerebral perfusion likely contribute to the recognized effect of this thermal condition in reducing orthostatic tolerance, although the mechanism(s) by which this occurs is not completely understood. The combination of intense whole-body exercise and environmental heat stress or dehydration-induced hyperthermia results in significant cardiovascular strain prior to exhaustion, which is characterized by reductions in cardiac output, stroke volume, arterial pressure and blood flow to the brain, skin and exercising muscle. These alterations in cardiovascular function and regulation late in heat stress/dehydration exercise might involve the interplay of both local and central reflexes, the contribution of which is presently unresolved.
C G Crandall; J González-Alonso
Related Documents :
6497824 - Physiological and perceptual responses to cyclic heat stress variations.
908684 - Prediction of heat tolerance from heart rate and rectal temperature in a temperate envi...
7184314 - The model of human thermoregulatory system for positive heat loads.
8240194 - Seven-day pyridostigmine administration and thermoregulation during rest and exercise i...
18307714 - Interventions in local communities and work sites through physical activity and nutriti...
12601634 - Ppargamma gene polymorphism is associated with exercise-mediated changes of insulin res...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-03-24
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  199     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-25     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  407-23     Citation Subset:  IM    
Department of Internal Medicine Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, and University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75231, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Baroreflex / physiology
Body Temperature / physiology
Cardiovascular Physiological Phenomena*
Cerebrovascular Circulation
Exercise / physiology
Extremities / anatomy & histology
Heat Stress Disorders / physiopathology*
Hemodynamics / physiology*
Muscle, Skeletal / blood supply
Regional Blood Flow / physiology
Skin / blood supply
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of mechanical factors in governing muscle blood flow.
Next Document:  Skeletal muscle fibre diversity and the underlying mechanisms.