| Cardiovascular effects of glucagon-like Peptide 1. | |
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MedLine Citation:
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PMID: 21034402 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Glucagon-like peptide-1 (GLP-1) is involved in satiety control and glucose homeostasis. Besides, GLP-1 has cardiovascular effects. In experimental models, GLP-1 increases cardiac output and exerts a direct vasodilatory effect. In animals with dilated cardiomyopathy GLP-1 improves left ventricular performance. Human data demonstrated that GLP-1 reduces arterial blood pressure, improves endothelial function in individuals with diabetes and left ventricular function in patients with heart failure. Administration of GLP-1 increases ejection fraction in acute myocardial infraction and reduces ischemia-reperfusion myocardial injury. Although more research is needed, these data suggest that GLP-1 may be used with promising results in patients with heart failure, acute myocardial infarction and revascularization procedures in addition to the standard therapy. |
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Authors:
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Athanasia Papazafiropoulou; Stavros I Pappas; Dimitrios Papadogiannis; Nicholas Tentolouris |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mini reviews in medicinal chemistry Volume: 11 ISSN: 1875-5607 ISO Abbreviation: Mini Rev Med Chem Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101094212 Medline TA: Mini Rev Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 97-105 Citation Subset: IM |
Affiliation:
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First Department of Propaedeutic and Internal Medicine, Athens University Medical School, 17 Agiou Thoma Street, GR-11527, Athens, Greece. ntentol@med.uoa.gr. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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