Document Detail


Cardiovascular effects of glucagon-like Peptide 1.
MedLine Citation:
PMID:  21034402     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Glucagon-like peptide-1 (GLP-1) is involved in satiety control and glucose homeostasis. Besides, GLP-1 has cardiovascular effects. In experimental models, GLP-1 increases cardiac output and exerts a direct vasodilatory effect. In animals with dilated cardiomyopathy GLP-1 improves left ventricular performance. Human data demonstrated that GLP-1 reduces arterial blood pressure, improves endothelial function in individuals with diabetes and left ventricular function in patients with heart failure. Administration of GLP-1 increases ejection fraction in acute myocardial infraction and reduces ischemia-reperfusion myocardial injury. Although more research is needed, these data suggest that GLP-1 may be used with promising results in patients with heart failure, acute myocardial infarction and revascularization procedures in addition to the standard therapy.
Authors:
Athanasia Papazafiropoulou; Stavros I Pappas; Dimitrios Papadogiannis; Nicholas Tentolouris
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  11     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
Affiliation:
First Department of Propaedeutic and Internal Medicine, Athens University Medical School, 17 Agiou Thoma Street, GR-11527, Athens, Greece. ntentol@med.uoa.gr.
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