Document Detail

Cardiovascular and behavioral response to auditory stimuli in boys with fragile X syndrome.
MedLine Citation:
PMID:  23143607     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to determine whether young boys with fragile X syndrome (FXS) exhibit abnormal physiological or behavioral responses to a moderately intense auditory stimulus, as heightened sensory reactivity is believed to contribute to problem behaviors in this population.
METHODS: We examined the physiological basis, via heart activity, of auditory startle in young boys with FXS (n = 22) compared with typically developing controls (n = 27). Associations with mental age, behavioral reactivity, and chronological age were examined.
RESULTS: Results suggest that older boys with FXS display increased cardiac reactivity to auditory input than younger boys with FXS that distinguishes them from typically developing controls. Higher mental age was associated with decreased latency to react.
CONCLUSIONS: Results contribute to increased understanding of the pathology in sensory processing in boys with FXS, which can inform refinement of the phenotype in young children with FXS and aid in the development of efficacious psychopharmacological and/or behavioral interventions.
Jane E Roberts; Anna C J Long; Lindsay M McCary; Amy N Quady; Bonnie S Rose; Dean Widrick; Grace Baranek
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-11
Journal Detail:
Title:  Journal of pediatric psychology     Volume:  38     ISSN:  1465-735X     ISO Abbreviation:  J Pediatr Psychol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-22     Completed Date:  2013-12-10     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  7801773     Medline TA:  J Pediatr Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  276-84     Citation Subset:  IM    
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MeSH Terms
Acoustic Stimulation*
Arousal / physiology*
Case-Control Studies
Child, Preschool
Cross-Sectional Studies
Fragile X Syndrome / physiopathology*,  psychology
Heart Rate / physiology*
Startle Reaction / physiology*
Grant Support
R01 MH090194/MH/NIMH NIH HHS; R01MH0901194-01A1/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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