Document Detail


Cardiotropin-1 and myocardial strain change heterogeneously in cardiomyopathy.
MedLine Citation:
PMID:  17574584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The pacing model of heart failure produces heterogeneous changes in wall stress and myocyte diameter. The purpose of this study was to measure regional changes in cardiotrophin-1 (CT-1), a cytokine thought to play a role in LV remodeling, and regional changes in LV strain as measured with magnetic resonance imaging. MATERIALS AND METHODS: Dilated cardiomyopathy was induced in nine mongrel dogs over 4 wk by rapid pacing using a right ventricular epicardial lead. Baseline CT-1 was measured from an apical myocardial biopsy, and regional CT-1 was measured from anterior, lateral, inferior, and septal walls after the induction of heart failure and in six control dogs. Tissue tagged images were divided into similar regions and minimal principal strain (MPS), ejection fraction, and ventricular volumes were compared after induction of heart failure. RESULTS: After induction of heart failure, LV ejection fraction and end-diastolic volume differed significantly from baseline (P < 0.01 and P = 0.02, respectively). Additionally, regional CT-1 and MPS were significantly different (P < 0.01 for both). Cardiotrophin-1 increased significantly in the inferior and septal walls (both P < 0.01) but not in the anterior or lateral walls (both P = NS). Minimum principal strain decreased significantly in the inferior and septal walls (both P < 0.01) but not in the anterior or lateral walls (both P = NS). CONCLUSION: The pacing model of heart failure produces heterogeneous changes in regional CT-1 and wall motion as measured by MPS. The greatest regional changes are closest to the pacemaker site: the inferior and septal walls. These differences in regional CT-1 may account for previously noted myocyte hypertrophy and preserved ventricular function in these regions.
Authors:
D Dean Potter; Philip A Araoz; Leong L Ng; David G Kruger; Jess L Thompson; Chad E Hamner; Joseph A Rysavy; Jayawant N Mandrekar; Thoralf M Sundt
Related Documents :
18752764 - Insights into myocardial mechanics in normal and pathologic states using newer echocard...
21630344 - Quantitative analysis of transmural gradients in myocardial perfusion magnetic resonanc...
20453384 - Myocardial deformation in acute myocarditis with normal left ventricular wall motion--a...
7600654 - A study in ventricular-ventricular interaction. single right ventricles compared with s...
1424024 - Coronary endothelial injury by cold crystalloid cardioplegic solution in neonatal lambs.
21822114 - Cost effectiveness of drug-eluting stents as compared with bare metal stents in patient...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-06-14
Journal Detail:
Title:  The Journal of surgical research     Volume:  141     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-08-30     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Surgery, University of Leicester, Leicester, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathy, Dilated / physiopathology*
Cytokines / analysis*
Dogs
Female
Magnetic Resonance Imaging
Male
Natriuretic Peptide, Brain / analysis
Ventricular Function, Left*
Grant Support
ID/Acronym/Agency:
R01-HL62291-04/HL/NHLBI NIH HHS; T32-HL-07776/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/cardiotrophin 1; 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Heparin-binding EGF-like growth factor decreases neutrophil-endothelial cell interactions.
Next Document:  Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine ...