Document Detail

Cardiotropic effect of extracardiac transplantation of embryonic human myoblasts to mice with bradycardia: various effects of cell material.
MedLine Citation:
PMID:  16142295     Owner:  NLM     Status:  MEDLINE    
Animals with bradycardia were detected in reproductive colony of mdx mice. Low pulse rate was associated with poor survival and predisposition to sudden death, but did not directly depend on the presence of dystrophin mutant gene or animal age. Heart rate increased in old mice with bradycardia after extracardial, intramuscular, and intravenous injection of human embryonic myoblasts. Stable normalization of the pulse was observed 2 weeks after transplantation, but early peak of heart rate was observed as early as 24 h after cell transplantation. Cell suspensions, which could contain stem cells (blood mononuclears and CD34+ lymphocytes), also corrected heart rhythm. Unlike the effect of myoblasts, cardiotropic effect of mononuclears was preceded by a period of tachycardia, while the effect of CD34+ lymphocytes was very unstable. The cardiotropic effect of myoblasts was combined with life span prolongation and certain rejuvenation in some animals. Erythrocytes and supernatant obtained during blood cell fractionation did not modify the heart rhythm in mice with bradycardia. After injection of myoblasts to mice with rare and normal pulses serum creatine kinase activity decreased with different rates. These data attest to a variety of biological effects of stem cells and/or their derivatives and to ambiguous mechanisms of these effects.
V N Yarygin; M A Stenina; L I Krivov; V I Savchuk; V F Sitnikov; A B Kuznetsov; Zh V Rudkovskaya; G T Sukhikh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  139     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Russian State Medical University, Moscow, Russia.
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MeSH Terms
Antigens, CD34 / analysis
Bradycardia / therapy*
Embryo, Mammalian / cytology
Heart Rate / genetics
Leukocytes, Mononuclear / transplantation
Lymphocytes / immunology
Mice, Inbred mdx
Myoblasts / transplantation*
Stem Cell Transplantation*
Reg. No./Substance:
0/Antigens, CD34

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