Document Detail

Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes.
MedLine Citation:
PMID:  12027405     Owner:  NLM     Status:  MEDLINE    
Cardiotrophin-1 (CT-1) is an Interleukin-6 family cytokine with known hypertrophic and protective effects in cardiac cells. CT-1 and the corticotrophin releasing hormone-like hormone urocortin protect cardiac myocytes by the same p42/44 mitogen activated protein kinase (p42/44 MAPK) dependent pathway. We investigated whether urocortin is also hypertrophic in cardiac myocytes and whether it shares a common pathway with CT-1 for this effect. Moreover, we also investigated, for the first time whether CT-1 and urocortin can induce hypertrophy in cultured adult as opposed to neonatal cardiac cells. Urocortin and CT-1 caused hypertrophy (as measured by an increase in cell area and enhanced protein: DNA ratio) in both adult and neonatal rat cultured cardiac myocytes. The hypertrophic effect of CT-1 was dependent on the signal transducer and activator of transcription 3 (STAT3) pathway but the hypertrophic effect of urocortin was independent of this pathway. In contrast, inhibition of the protective p42/p44 MAPK pathway has no effect on the hypertrophic effect of CT-1 or urocortin. Additionally, inhibition of the STAT3 pathway has no effect on the protective effect of CT-1 or urocortin. These results identify urocortin as a novel hypertrophic and protective agent whose hypertrophic effect is mediated by a distinct pathway to that activated by CT-1, although the two factors mediate protection via the same pathway.
Julia E Railson; Zhihong Liao; Bhawanjit K Brar; Joanna C Buddle; Diane Pennica; Anastasis Stephanou; David S Latchman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytokine     Volume:  17     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-24     Completed Date:  2002-12-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-53     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd. All rights reserved.
Medical Molecular Biology Unit, University College London, 30 Guilford Street, London, WC1N 1EH, UK.
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MeSH Terms
Animals, Newborn
Cell Death
Cells, Cultured
Corticotropin-Releasing Hormone / metabolism,  physiology*
Cytokines / physiology*
DNA / metabolism
DNA-Binding Proteins / metabolism
Dose-Response Relationship, Drug
Genes, Dominant
In Situ Nick-End Labeling
Mitogen-Activated Protein Kinase 1 / metabolism*
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases / metabolism*
Myocardium / cytology*,  metabolism
Neuroprotective Agents
Plasmids / metabolism
STAT3 Transcription Factor
Time Factors
Trans-Activators / metabolism
Reg. No./Substance:
0/Cytokines; 0/DNA-Binding Proteins; 0/Neuroprotective Agents; 0/STAT3 Transcription Factor; 0/Stat3 protein, rat; 0/Trans-Activators; 0/Urocortins; 0/cardiotrophin 1; 9007-49-2/DNA; 9015-71-8/Corticotropin-Releasing Hormone; EC Protein Kinase 1; EC Protein Kinase 3; EC Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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