Document Detail

Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis.
MedLine Citation:
PMID:  17326158     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: CT-1-/- mice are highly sensitive to Fas-mediated apoptosis due in part to deficient STAT-3 activation and inadequate control of calpain activity during the apoptotic process. Our data show that CT-1 is a natural defense of the liver against apoptosis. This cytokine may have therapeutic potential.
Juan M Marquès; Idoia Belza; Bettina Holtmann; Diane Pennica; Jesus Prieto; Matilde Bustos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  45     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-03-26     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  639-48     Citation Subset:  IM    
Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Navarra, Spain.
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MeSH Terms
Antibodies / pharmacology
Antigens, CD95 / immunology
Apoptosis / drug effects,  physiology*
Calcium-Binding Proteins / genetics,  physiology
Cytokines / genetics,  physiology*
Gene Expression Regulation
Hepatocytes / pathology,  physiology*
Liver / pathology*,  physiology
Mice, Inbred C57BL
Mice, Knockout
Peroxidases / genetics,  physiology
Peroxiredoxin III
Receptors, Tumor Necrosis Factor, Type I / genetics,  physiology
STAT3 Transcription Factor / genetics,  physiology
Reg. No./Substance:
0/Antibodies; 0/Antigens, CD95; 0/Calcium-Binding Proteins; 0/Cytokines; 0/Fas protein, mouse; 0/Prdx3 protein, mouse; 0/Receptors, Tumor Necrosis Factor, Type I; 0/STAT3 Transcription Factor; 0/Stat3 protein, mouse; 0/Tnfrsf1a protein, mouse; 0/cardiotrophin 1; 79079-11-1/calpastatin; EC 1.11.1.-/Peroxidases; EC III; EC

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