| Cardiotoxicity of trastuzumab (herceptin) in chick embryos. | |
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MedLine Citation:
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PMID: 12808308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiac toxicity of trastuzumab was studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. Trastuzumab 5 mg/egg (low dose) or 15 mg/egg (high dose) was injected into the air sac of a fertilized egg on the 16th day of incubation. Electrocardiograms (ECGs) were recorded 0 to 60 min after the injection. After low dosing of trastuzumab, the heart rate was not different compared with the control. However, the heart rate was significantly decreased by high dosing of trastuzumab. In addition, arrhythmia was produced by high dosing of trastuzumab. These findings indicate that trastuzumab has a marked dose- and time-dependent influence on the heart rate in chick embryos. |
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Authors:
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Yuji Yoshiyama; Takashi Sugiyama; Motoko Kanke |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 26 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-16 Completed Date: 2004-01-15 Revised Date: 2013-05-08 |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 893-5 Citation Subset: IM |
Affiliation:
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Division of Clinical Pharmacy, Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. yoshiyama-yj@kyoritsu-ph.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Use Alternatives
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methods* Animals Antibodies, Monoclonal / toxicity* Antibodies, Monoclonal, Humanized Antineoplastic Agents / toxicity* Chick Embryo Electrocardiography Heart / drug effects*, embryology Heart Rate / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antineoplastic Agents; P188ANX8CK/trastuzumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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