Document Detail

Cardiotoxicity and hypertension in rats after oral lead exposure.
MedLine Citation:
PMID:  1935709     Owner:  NLM     Status:  MEDLINE    
The rats were exposed to lead (0.25, 0.5 and 1.0 per cent lead acetate through drinking water) for 90 days to study its effect on some physiological and morphological parameters of the cardiovascular system. Blood lead levels increased in a dose dependent manner but heart tissue showed rise at only two higher doses in exposed animals. The two higher doses of lead resulted in an increased arterial blood pressure and calcium influx in atrial trabeculae and papillary muscles. No marked pathological or histochemical changes were observed in heart tissue excepting congestion and slightly reduced activity of succinic dehydrogenase in the highest dosed group. It was concluded that lead exposure through drinking water may produce increased arterial blood pressure and minor changes in the myocardium. Whether these changes are mediated through the effect of lead on the calcium transport needs further investigation.
B Lal; R C Murthy; M Anand; S V Chandra; R Kumar; O Tripathi; R C Srimal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  14     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-25     Completed Date:  1991-11-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-18     Citation Subset:  IM    
Industrial Toxicology Research Centre, Lucknow, India.
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MeSH Terms
Administration, Oral
Blood Pressure / drug effects*
Body Weight / drug effects
Calcium / metabolism
Dose-Response Relationship, Drug
Heart / drug effects*
Lead / toxicity*
Myocardium / metabolism,  pathology
Reg. No./Substance:
7439-92-1/Lead; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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