Document Detail


Cardiotoxicity and hypertension in rats after oral lead exposure.
MedLine Citation:
PMID:  1935709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rats were exposed to lead (0.25, 0.5 and 1.0 per cent lead acetate through drinking water) for 90 days to study its effect on some physiological and morphological parameters of the cardiovascular system. Blood lead levels increased in a dose dependent manner but heart tissue showed rise at only two higher doses in exposed animals. The two higher doses of lead resulted in an increased arterial blood pressure and calcium influx in atrial trabeculae and papillary muscles. No marked pathological or histochemical changes were observed in heart tissue excepting congestion and slightly reduced activity of succinic dehydrogenase in the highest dosed group. It was concluded that lead exposure through drinking water may produce increased arterial blood pressure and minor changes in the myocardium. Whether these changes are mediated through the effect of lead on the calcium transport needs further investigation.
Authors:
B Lal; R C Murthy; M Anand; S V Chandra; R Kumar; O Tripathi; R C Srimal
Related Documents :
25312339 - The effect of flammer-syndrome on retinal venous pressure.
6804729 - Infusions of chemicals into the brain and the development of sustained elevations of bl...
19108179 - The action of eledoisin on the systemic arterial blood pressure of some experimental an...
25427289 - The influence of positive end-expiratory pressure on surgical field conditions during f...
25294299 - Beetroot supplementation lowers daily systolic blood pressure in older, overweight subj...
472749 - Baroreceptor activation reduces reactivity to noxious stimulation: implications for hyp...
20843589 - The effects of plantar fasciitis and pain on plantar pressure distribution of recreatio...
19199199 - Military diving training improved arterial compliance.
18641799 - The effects of positive end-expiratory pressure in alveolar recruitment during mechanic...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  14     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-25     Completed Date:  1991-11-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-18     Citation Subset:  IM    
Affiliation:
Industrial Toxicology Research Centre, Lucknow, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Blood Pressure / drug effects*
Body Weight / drug effects
Calcium / metabolism
Dose-Response Relationship, Drug
Electrocardiography
Heart / drug effects*
Lead / toxicity*
Male
Myocardium / metabolism,  pathology
Rats
Chemical
Reg. No./Substance:
7439-92-1/Lead; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of subacute administration of isoniazid and pyridoxine on lipids in plasma, liver and adipose...
Next Document:  Incidence and treatment of deviation of nasal septum in newborns.