Document Detail

Cardiotoxic effects of adriamycin and mitochondrial oxidation in rat cardiac tissue.
MedLine Citation:
PMID:  3836126     Owner:  NLM     Status:  MEDLINE    
Rats were subjected to chronic treatment with adriamycin (ADR). Significant alterations of ECG tracings were induced, starting from the third week of treatment. These alterations were related to mitochondrial damage of the heart tissue. A decrease of respiration rate in phosphorylating conditions was observed in isolated organelles over a period of three weeks. Meanwhile, adriamycinol (ADRol) concentration in heart extracts increased during chronic treatment.
U Montali; M Del Tacca; C Bernardini; D Segnini; G Solaini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  11     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1985  
Date Detail:
Created Date:  1986-07-25     Completed Date:  1986-07-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  219-22     Citation Subset:  IM    
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MeSH Terms
Chromatography, High Pressure Liquid
Doxorubicin / analogs & derivatives,  blood,  toxicity*
Heart / drug effects*
Injections, Intravenous
Mitochondria, Heart / metabolism*
Oxidative Phosphorylation / drug effects
Oxygen Consumption
Rats, Inbred Strains
Reg. No./Substance:
141434-67-5/adriamycinol; 23214-92-8/Doxorubicin

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