| Cardiotonic effects of anthopleurin-A (AP-A), a polypeptide from a sea anemone, in dogs with a coronary artery stenosis. | |
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MedLine Citation:
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PMID: 3987818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The positive inotropic effect of AP-A was studied in anesthetized dogs with a severe stenosis of the left anterior descending coronary artery. Peak positive dP/dt (mm Hg/s) and % segment shortening (%SS) were used as indices of contractile function. AP-A (1.5-5.0 micrograms/kg, i.v.) produced positive inotropic effects globally (dP/dt, 1700 +/- 100 to 2650 +/- 250 mm Hg/s) and locally in the ischemic zone (%SS, 6.7 +/- 1.7 to 13.7 +/- 1.5%) without changing heart rate, mean arterial pressure or myocardial blood flow. These data suggest that AP-A may be potentially useful in the management of heart failure. |
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Authors:
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G J Gross; D C Warltier; H F Hardman; S Shibata |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 110 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-06-18 Completed Date: 1985-06-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 271-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiotonic Agents* Coronary Circulation / drug effects Coronary Disease / physiopathology* Dogs Female Heart Rate / drug effects Male Myocardial Contraction / drug effects Peptides / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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HL 08311/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Peptides; 60880-63-9/anthopleurin-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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