Document Detail

Cardiostimulant effects of urotensin-II in human heart in vitro.
MedLine Citation:
PMID:  11156554     Owner:  NLM     Status:  MEDLINE    
The effects of the recently identified human peptide urotensin-II (hU-II) were investigated on human cardiac muscle contractility and coronary artery tone. In right atrial trabeculae from non-failing hearts, hU-II caused a concentration-dependent increase in contractile force (pEC(50)=9.5+/-0.1; E(max)=31.3+/-4.8% compared to 9.25 mM Ca(2+); n=9) with no change in contraction duration. In right ventricular trabeculae from explanted hearts, 20 nM hU-II caused a small increase in contractile force (7.8+/-1.4% compared to 9.25 mM Ca(2+); n=3/6 tissues from 2 out of 4 patients). The peptide caused arrhythmic contractions in 3/26 right atrial trabeculae from 3/9 patients in an experimental model of arrhythmia and therefore has less potential to cause arrhythmias than ET-1. hU-II (20 nM) increased tone (17.9% of the response to 90 mM KCI) in 7/7 tissues from 1 patient, with no response detected in 8/8 tissues from 2 patients. hU-II is a potent cardiac stimulant with low efficacy.
F D Russell; P Molenaar; D M O'Brien
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of pharmacology     Volume:  132     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-05-24     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
The National Heart Foundation and Prince Charles Hospital Foundation Cardiovascular Research Centre, Department of Medicine, The Prince Charles Hospital, Chermside, Queensland 4032, Australia.
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MeSH Terms
Arrhythmias, Cardiac / chemically induced,  physiopathology
Cardiotonic Agents / pharmacology*
Coronary Vessels / drug effects
Heart / drug effects*
Heart Atria / drug effects
Heart Ventricles / drug effects
Muscle Tonus / drug effects
Muscle, Smooth, Vascular / drug effects
Myocardial Contraction / drug effects
Urotensins / pharmacology*
Reg. No./Substance:
0/Cardiotonic Agents; 0/Urotensins; 9047-55-6/urotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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