Document Detail

Cardiorespiratory responses to sudden release of circulatory occlusion during exercise.
MedLine Citation:
PMID:  515564     Owner:  NLM     Status:  MEDLINE    
Cardiovascular and respiratory parameters were measured during and after release of pressure in thigh cuffs which occluded circulation to the legs of four human subjects exercising on a bicycle ergometer. The subjects exercised at 200 kg/min while thigh cuffs were inflated for 4 min and then released. Responses from 6 to 8 identical experiments were ensemble averaged so the precise timing of delays could be obtained. Five to ten seconds following cuff release, end-tidal CO2 increased, marking arrival of the trapped blood at the lungs. Ten to eighteen seconds after this increase in end-tidal CO2, ventilation, respiratory rate and tidal volume increased. This delay in ventilation must have resulted in an increase in arterial PCO2 and suggests that arterial chemoreceptors mediated the responses, and that no venous chemoreceptors or CO2-flux or disequilibrium receptors in the lung need be postulated.
J R Hildebrandt; R K Winn; J Hildebrandt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  38     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1980-02-26     Completed Date:  1980-02-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  83-92     Citation Subset:  IM; S    
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MeSH Terms
Heart / physiology*
Heart Rate
Ischemia / physiopathology*
Leg / blood supply
Lung / physiology
Physical Exertion*
Tidal Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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