Document Detail

Cardiorespiratory fitness is related to physical inactivity, metabolic risk factors, and atherosclerotic burden in glucose-intolerant renal transplant recipients.
MedLine Citation:
PMID:  17699359     Owner:  NLM     Status:  MEDLINE    
The mechanisms of reduced cardiorespiratory fitness (CF) in renal transplant recipients (RTR) have not been studied closely. This study evaluated the relationships between CF and specific cardiovascular risk factors (metabolic syndrome [MS], physical inactivity, myocardial ischemia, and atherosclerotic burden) in glucose-intolerant RTR. Data were recorded on 71 glucose-intolerant RTR (mean age 55 yr; 55% male; median transplant duration 5.7 yr). MS was defined using National Cholesterol Education Programme Adult Treatment Panel III criteria. Resting and exercise stress echocardiography were performed, and myocardial ischemia was identified by new or worsening wall motion abnormalities. Cardiorespiratory fitness was determined using peak oxygen uptake (VO(2)) by expired gas analysis. Atherosclerotic burden was assessed by carotid intima-media thickness (IMT). Mean peak VO(2) was 19 +/- 7 ml/kg per min and was significantly lower than predicted peak VO(2) (29 +/- 6 ml/kg per min; P < 0.001). Patients with MS (63%) had reduced CF (17 +/- 6 versus 22 +/- 8 ml/kg per min; P = 0.001) and were more likely to be physically inactive (76 versus 48%; P = 0.02). CF was reduced in 14 patients with myocardial ischemia (15 +/- 3 versus 20 +/- 7 ml/kg per min; P = 0.05). CF was positively correlated with male gender, height, and physical activity and inversely correlated with number of MS risk factors and IMT (adjusted R(2) = 0.66). Carotid IMT added incremental value to clinical variables in determining VO(2) (adjusted R(2) = 0.65 versus 0.63; P = 0.04). Reduced CF is associated with physical inactivity, MS, and atherosclerotic burden in glucose-intolerant RTR. Further studies should address whether increasing exercise and modifying MS risk factors improve CF in RTR.
Kirsten Armstrong; Dhrubo Rakhit; Leanne Jeffriess; David Johnson; Rodel Leano; John Prins; Luke Garske; Thomas Marwick; Nicole Isbel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-04
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  1     ISSN:  1555-905X     ISO Abbreviation:  -     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-09-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1275-83     Citation Subset:  IM    
Department of Nephrology, University of Queensland at Princess Alexandra Hospital, Brisbane, Queensland, Australia.
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MeSH Terms
Atherosclerosis / epidemiology*
Cardiovascular Diseases / epidemiology
Glucose Intolerance / complications,  epidemiology,  physiopathology*
Heart / physiology*
Kidney Transplantation / adverse effects,  physiology*
Middle Aged
Myocardial Ischemia / epidemiology
Oxygen Consumption
Physical Fitness*
Respiratory Physiological Phenomena*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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