Document Detail

Cardiorespiratory effects of a tiletamine/zolazepam-ketamine-detomidine combination in horses.
MedLine Citation:
PMID:  10376910     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine cardiorespiratory effects of a tiletamine/zolazepam-ketamine-detomidine (TZKD) combination in horses. ANIMALS: 8 healthy adult horses. PROCEDURE: Horses were instrumented for measurement of cardiorespiratory, acid-base, and electrolyte values. Each horse was given xylazine (0.44 mg/kg of body weight, IV) 10 to 15 minutes prior to induction of recumbency by administration of the TZKD combination. Cardiorespiratory, acid-base, and electrolyte values were measured at 5-minute intervals for > or =30 minutes. RESULTS: All horses became recumbent within 1 minute after IV administration of TZKD. Mean +/- SD duration of recumbency was 40+/-8 minutes. All horses regained standing position after < or =2 attempts. Quality of anesthesia and analgesia was determined to be satisfactory in all horses. Xylazine induced decreases in respiratory rate, heart rate, cardiac output, maximum rate of increase of right ventricular pressure, and rate pressure product. The PaCO2, right atrial pressure, and peripheral vascular resistance increased, whereas blood temperature, PO2, pHa, HCO3-, PCV, total solids, Na, and K values remained unchanged. Subsequent administration of TZKD caused right atrial pressure and PaCO2 to increase and PaO2 to decrease, compared with values obtained after xylazine administration. Remaining cardiorespiratory, acid-base, hematologic, and electrolyte values did not differ from those obtained after xylazine administration. CONCLUSION: IV administration of TZKD induces short-term anesthesia in horses. Potential advantages of this drug combination are the small volume of drug administered; minimal cardiorespiratory depression; quality of induction and maintenance of, and recovery from, anesthesia; and duration of drug effects.
W W Muir; J E Gadawski; D A Grosenbaugh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  60     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-03     Completed Date:  1999-08-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  770-4     Citation Subset:  IM    
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA.
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MeSH Terms
Analgesics / pharmacology
Anesthetics, Dissociative / pharmacology
Blood Pressure / drug effects
Body Temperature / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects
Drug Interactions
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypnotics and Sedatives / pharmacology*
Imidazoles / pharmacology*
Ketamine / pharmacology*
Oxygen / blood
Partial Pressure
Potassium / blood
Respiratory Mechanics / drug effects*
Sodium / blood
Tiletamine / pharmacology*
Zolazepam / pharmacology*
Reg. No./Substance:
0/Analgesics; 0/Anesthetics, Dissociative; 0/Hypnotics and Sedatives; 0/Imidazoles; 124-38-9/Carbon Dioxide; 14176-49-9/Tiletamine; 31352-82-6/Zolazepam; 6740-88-1/Ketamine; 7440-09-7/Potassium; 7440-23-5/Sodium; 76631-46-4/detomidine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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