Document Detail


Cardiorespiratory effects of inelastic chest wall restriction.
MedLine Citation:
PMID:  12015356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the effects of chest wall restriction (CWR) on cardiorespiratory function at rest and during exercise in healthy subjects in an attempt to approximate the cardiorespiratory interactions observed in clinical conditions that result in restrictive lung and/or chest wall changes and a reduced intrathoracic space. Canvas straps were applied around the thorax and abdomen so that vital capacity was reduced by >35%. Data were acquired at rest and during cycle ergometry at 25 and 45% of peak workloads. CWR elicited significant increases in the flow-resistive work performed on the lung (160%) and the gastric pressure-time integral (>400%) at the higher workload, but it resulted in a decrease in the elastic work performed on the lung (56%) compared with control conditions. With CWR, heart rate increased and stroke volume (SV) fell, resulting in >10% fall in cardiac output at rest and during exercise at matched workloads (P < 0.05). Blood pressure and catecholamines were significantly elevated during CWR exercise conditions (P < 0.05). We conclude that CWR significantly impairs SV during exercise and that a compensatory increase in heart rate does not prevent a significant reduction in cardiac output. O(2) consumption appears to be maintained via increased extraction and a redistribution of blood flow via sympathetic activation.
Authors:
Jordan D Miller; Kenneth C Beck; Michael J Joyner; A Glenn Brice; Bruce D Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  92     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-16     Completed Date:  2002-10-23     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2419-28     Citation Subset:  IM    
Affiliation:
Department of Anesthesia Research, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Pressure / physiology
Cardiac Output / physiology
Elasticity
Exercise Test
Female
Heart / physiology*
Humans
Immobilization
Lung / physiology
Lung Volume Measurements
Male
Neurosecretory Systems
Pressure
Pulmonary Gas Exchange
Pulmonary Ventilation
Respiration
Respiratory Mechanics
Respiratory Muscles / physiology
Respiratory Physiological Phenomena*
Thorax / physiology*
Grant Support
ID/Acronym/Agency:
HL-46493/HL/NHLBI NIH HHS; HL-52230/HL/NHLBI NIH HHS; M01-RR-00585/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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